Category: Neuromuscular Blockers

Drug Nomenclature Synonyms: (+)-Tubocurarine Chloride Hydrochloride Pentahydrate; d-Tubocurarine Chloride; Cloruro de tubocurarina; Tubocurarina, cloruro de; Tubocurarini Chloridum; Tubocurarinii Chloridum Pentahydricum; Tubokurariinikloridi; Tubokurarin-klorid; Tubokurarinium-chlorid pentahydrát; Tubokurarinklorid; Tubokurarino chloridas BAN: Tubocurarine Chloride INN: Tubocurarine Chloride [rINN (en)] INN: Cloruro de tubocurarina [rINN (es)] INN: Tubocurarine, Chlorure de [rINN (fr)] INN: Tubocurarini Chloridum [rINN (la)] INN: Тубокурарина Хлорид [rINN (ru)] Chemical name: (+)-7´,12´-Dihydroxy-6,6´-dimethoxy-2,2´,2´-trimethyltubocuraranium dichloride pentahydrate Molecular formula: C37H42Cl2N2O6,5H2O =771.7 CAS: 57-95-4 (tubocurarine); 57-94-3 (anhydrous tubocurarine chloride); 6989-98-6 (tubocurarine chloride, pentahydrate) ATC code: M03AA02 Read code: y03Jo Pharmacopoeias. In China Europe Japan, and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Tubocurarine Chloride). A …

Patients given a neuromuscular blocker should always have their respiration assisted or controlled until the drug has been inactivated or antagonised. Suxamethonium chloride is contra-indicated in patients with atypical plasma cholinesterase and should be used with caution in patients with reduced plasma cholinesterase activity (see below), which may occur in certain disease states and following exposure to certain drugs. Plasma cholinesterase concentrations fall during pregnancy and the puerperium and therefore maternal paralysis may be mildly prolonged. Suxamethonium is contra-indicated in patients with burns, massive trauma, renal impairment with a raised plasma-potassium concentration, severe long-lasting sepsis, and severe hyperkalaemia, since suxamethonium-induced rises in plasma-potassium concentration can have serious consequences in such patients; …

Drug Nomenclature Synonyms: Bromuro de rocuronio; Org-9426; Rocuronii Bromidum; Rocuronio, bromuro de; Rokuronium-bromid; Rokuroniumbromid; Rokuroniumbromidi BAN: Rocuronium Bromide USAN: Rocuronium Bromide INN: Rocuronium Bromide [rINN (en)] INN: Bromuro de rocuronio [rINN (es)] INN: Rocuronium, Bromure de [rINN (fr)] INN: Rocuronii Bromidum [rINN (la)] INN: Рокурония Бромид [rINN (ru)] Chemical name: 1-Allyl-1-(3α,17β-dihydroxy-2β-morpholino-5α-androstan-16β-yl)pyrrolidinium bromide 17-acetate; 1-(17β-Acetoxy-3α-hydroxy-2β-morpholino-5α-androstan-16β-yl)-1-allylpyrrolidinium bromide Molecular formula: C32H53BrN2O4 =609.7 CAS: 119302-91-9 ATC code: M03AC09 Read code: y04GU Pharmacopoeias. In Europe. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Rocuronium Bromide). An almost white or pale yellow, slightly hygroscopic, powder. Freely soluble in water and in dehydrated alcohol. A 1.0% solution in water …

Drug Nomenclature Synonyms: Bromuro de pipecuronio; Pipecurium Bromide; Pipecuronii Bromidum; Pipecuronio, bromuro de; Pipekuroniumbromid; Pipekuroniumbromidi; RGH-1106 BAN: Pipecuronium Bromide USAN: Pipecuronium Bromide INN: Pipecuronium Bromide [rINN (en)] INN: Bromuro de pipecuronio [rINN (es)] INN: Pipécuronium, Bromure de [rINN (fr)] INN: Pipecuronii Bromidum [rINN (la)] INN: Пипекурония Бромид [rINN (ru)] Chemical name: 1,1,1´,1´-Tetramethyl-4,4´-(3α,17β-diacetoxy-5α-androstan-2β,16β-diyl)dipiperazinium dibromide Molecular formula: C35H62Br2N4O4 =762.7 CAS: 52212-02-9 (anhydrous pipecuronium bromide); 68399-57-5 (pipecuronium bromide dihydrate) ATC code: M03AC06 Profile Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker (see Atracurium). Pipecuronium is reported to have no significant cardiovascular adverse effects or histamine-related effects. On intravenous injection muscle relaxation occurs within 2.5 to 3 minutes with a duration of action …

Drug Nomenclature Synonyms: Bromuro de pancuronio; NA-97; Org-NA-97; Pancuronii Bromidum; Pancuronio, bromuro de; Pankuronio bromidas; Pankuronium-bromid; Pankuroniumbromid; Pankuroniumbromidi BAN: Pancuronium Bromide USAN: Pancuronium Bromide INN: Pancuronium Bromide [rINN (en)] INN: Bromuro de pancuronio [rINN (es)] INN: Pancuronium, Bromure de [rINN (fr)] INN: Pancuronii Bromidum [rINN (la)] INN: Панкурония Бромид [rINN (ru)] Chemical name: 1,1´-(3α,17β-Diacetoxy-5α-androstan-2β,16β-ylene)bis(1-methylpiperidinium) dibromide Molecular formula: C35H60Br2N2O4 =732.7 CAS: 15500-66-0 ATC code: M03AC01 Read code: y03Jl Pharmacopoeias. In Europe, Japan, and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Pancuronium Bromide). White, yellowish-white, or slightly pink, hygroscopic crystalline powder. Very soluble to freely soluble in water; freely soluble in …

Drug Nomenclature Synonyms: BW-A938U; Cloruro de doxacurio; Doksakuriumkloridi; Doxacurii Chloridum; Doxacurio, cloruro de; Doxakuriumklorid BAN: Doxacurium Chloride USAN: Doxacurium Chloride INN: Doxacurium Chloride [rINN (en)] INN: Cloruro de doxacurio [rINN (es)] INN: Doxacurium, Chlorure de [rINN (fr)] INN: Doxacurii Chloridum [rINN (la)] INN: Доксакурия Хлорид [rINN (ru)] Chemical name: A mixture of the (1R,1´S,2S,2´R), (1R,1´R,2S,2´S), and (1S,1´S,2R,2´R) stereoisomers (a meso isomer and two enantiomers respectively) of 1,1´,2,2´,3,3´,4,4´-octahydro-6,6´,7,7´,8,8´-hexamethoxy-2,2´-dimethyl-1,1´-bis(3,4,5-trimethoxybenzyl)-2,2´-[butanedioylbis(oxytrimethylene)]di-isoquinolinium dichloride, all of which are in a trans configuration at the 1 and 2 positions of the isoquinolinium rings Molecular formula: C56H78Cl2N2O16 =1106.1 CAS: 133814-18-3 (doxacurium); 106819-53-8 (doxacurium chloride, meso isomer); 83348-52-1 (doxacurium chloride, total racemate) …