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Pilocarpine is authorised in the world under the following brand names: Akarpine, Almocarpine, Ami-Pilo, Amistura P, Epicar, Isopto Carpine, Isoptocarpine, Mi-Pilo, Mi-Pilo Ophth Sol, Minims Pilocarpine, Miocarpine, Mistura P, Ocu-Carpine, Ocusert P 20, Ocusert Pilo, Ocusert Pilo-20, Ocusert Pilo-40, P.V. Carpine Liquifilm, Pilagan, Pilocar, Pilocar SMP, Pilocarpal, Pilocarpol, Pilocel, Pilokarpol, Pilomiotin, Pilopine HS, Piloptic-1, Piloptic-1/2, Piloptic-2, Piloptic-3, Piloptic-4, Piloptic-6, Pilostat, Pilovisc, Salagen, Sno Pilo, Syncarpine.

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Questions

[1] A 62-year-old woman is noted to have open-angle glaucoma. She inadvertently applies excessive pilocarpine to her eyes. This may result in which of the following?

A. Bronchial smooth muscle dilation

B. Decreased gastrointestinal motility

C. Dilation of blood vessels

D. Mydriasis

[2] Muscarinic cholinergic agonists

A. Activate inhibitory G-proteins (Gi)

B. Decrease production of IP3

C. Decrease release of intracellular calcium

D. Inhibit the activity of phospholipase C

[3] Choline esters like carbachol are most likely to cause which of the following adverse effects?

A. Anhydrosis (dry skin)

B. Delirium

C. Salivation

D. Tachycardia (rapid heart rate)

Answers

[1] C. Excessive pilocarpine may initially result in dilation of blood vessels with a drop in blood pressure and a compensatory reflex stimulation of heart rate. Higher levels will directly inhibit the heart rate. In addition, pilocarpine stimulation of muscarinic cholinoreceptors can result in miosis, bronchial smooth muscle dilation, and increased GI motility.

[2] A. In addition to activating inhibitory G-proteins (Gi), muscarinic cholinergic agonists stimulate the activity of phospholipase C, increase production of IP3, and increase release of intracellular calcium.

[3] C. Diarrhea, salivation, and lacrimation may be seen. The heart rate is usually slowed. Choline esters do not cross the blood-brain barrier, and therefore delirium is not an adverse effect.

Pharmacology pearls

Cholinoreceptors are classified as either nicotinic or muscarinic.

Muscarinic cholinoreceptors are localized at organs such as the heart, causing a negative chronotropic effect.

Stimulation of muscarinic receptors in the smooth muscle, exocrine glands, and vascular endothelium cause bronchoconstriction, increased acid secretion, and vasodilation.

Methacholine and bethanechol are highly selective for muscarinic cholinoreceptors.

Cholinomimetic agents, including anticholinesterase inhibitors, are precluded for treatment of gastrointestinal or urinary tract disease because of mechanical obstruction, where therapy can result in increased pressure and possible perforation. They are also not indicated for patients with asthma.

Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

Synonyms of Pilocarpine *:

Adsorbocarpine, Beta-pilocarpine hydrochloride, Pilocarpin, Pilocarpine chloride, Pilocarpine HCl, Pilocarpine hydrochloride, Pilocarpine monohydrochloride, Pilocarpine muriate, Pilokarpin, Pilokarpin monohydrochloride, Spersacarpine, Spersacarpine hydrochloride

* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.

How can i get Pilocarpine online over the counter?
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Dosage forms of Pilocarpine:

Name, Strength, Form, Route
Pilocarpine Gel Ophthalmic
Pilocarpine Liquid Ophthalmic
Pilocarpine Liquid Oral
Pilocarpine Solution Ophthalmic
Pilocarpine Solution / drops Oral
Pilocarpine Tablet Oral

Therapeutic classes of Pilocarpine:

Cholinergic Agents, Miotics, Muscarinic Agonists

Do I need a Prescription to buy Pilocarpine in Online Pharmasy?
No. You can purchase Pilocarpine without a prescription!

Common brands (equivalents) of Pilocarpine, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
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