Overview The first generation of selective COX-2 inhibitors, such as rofecoxib (Merck’s Vioxx) and celecoxib (Pfizer’s Celebrex), demonstrated their ability to reduce gastrointestinal (GI) side effects in comparison with traditional nons-teroidal anti-inflammatory drugs (NSAIDs), which suppress the isoforms of COX, COX-1 and COX-2, less discriminately. These agents still cause some degree of GI upset, however, so R&D efforts have been focused on developing a second generation of inhibitors that have an even higher degree of selectivity for COX-2. Valdecoxib (Pfizer’s Bextra) and etoricoxib (Merck’s Arcoxia) were the first of this second generation of selective COX-2 inhibitors to be launched; they are reviewed in “Current Therapies.” Concerns regarding …
[ Continue Reading... ]Tags: Arcoxia
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Etoricoxib is authorised in the world under the following brand names: Algix, Arcoxia, Nucoxia, Tauxib.
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Overview As a result of the GI side effects that occur with traditional NSAIDs, considerable effort has been expended in developing new agents with less GI toxicity. In 1991, researchers achieved a major breakthrough when they discovered that two distinct isoforms of COX exist. COX-1, or constitutive cyclooxygenase, is present in cells under normal physiological conditions and stimulates the synthesis of prostaglandins that help regulate renal function, blood flow, and platelet activity and help protect the mucous membrane along the GI tract. COX-2, or inducible cyclooxygenase, is expressed only under pathological conditions. Its production is induced by proinflammatory cytokines, mitogens, or endotoxins, and it stimulates the production of prostaglandins …
[ Continue Reading... ]Merck’s second-generation COX-2 inhibitor, etoricoxib (Arcoxia), was approved in the United Kingdom in April 2002 for the treatment of symptomatic pain relief in OA, rheumatoid arthritis, acute gouty arthritis, chronic musculoskeletal pain, acute pain associated with dental surgery, and primary dysmenorrhea. By October 2002, etoricoxib had been approved in Europe under the Mutual Recognition Procedure, and it has since launched in Italy and Spain. The U.K. launch came on the heels of the company’s withdrawal of its initial NDA for approval in the United States, following the FDA’s request for additional data on etoricoxib’s cardiovascular safety. In December 2003, Merck submitted an expanded NDA, seeking indications for the treatment of OA, …
[ Continue Reading... ]Overview The conventional Disease-modifying antirheumatic drug class includes a wide range of agents as diverse as antimalarials, cytotoxics, and immunosuppressants. Unlike anti-inflammatories, which provide symptomatic relief without altering the natural course of the disease, Disease-modifying antirheumatic drugs lack a direct analgesic effect but have the potential to slow or prevent joint damage in rheumatoid arthritis patients. It may take months of treatment for the clinical benefits of conventional Disease-modifying antirheumatic drugs to become apparent, and some clinicians and researchers use the term slow-acting antirheumatic drugs to indicate that these agents take longer than anti-inflammatories to achieve an effect. However, Disease-modifying antirheumatic drugs is the more widely used …
[ Continue Reading... ]Spanish And French Translations Of Common Medication Words:
| English | Spanish | French |
|---|---|---|
| Medications | Medicamentos | Médicaments |
| Tablets | Comprimidos | Comprimés |
| Capsules | Cápsulas | Gélules |
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:| 1 Walgreens | 2 CVS | 3 Walmart | 4 Rite Aid | 5 Kroger |
| 6 Target | 7 Kaiser Permanente | 8 Sears | 9 Cardinal Health | 10 Dominick's |
Pharmacy-led chains in the United Kingdom
| Alliance Boots | The Co-operative | Lloyds Pharmacy |
| Numark | Rowlands Pharmacy | Superdrug |
Synonyms of Etoricoxib *:
etoricoxib, MK-663
* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.
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Dosage forms of Etoricoxib:
| Name, Strength, Form, Route |
|---|
| Etoricoxib |
Therapeutic classes of Etoricoxib:
Cyclooxygenase Inhibitors
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Common brands (equivalents) of Etoricoxib, which people buy in pharmacies of the world:
(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
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