Acebutolol

What is Acebutolol?

Acebutolol is a beta-1 adrenergic blocking agent used in the management of hypertension and certain types of arrhythmias. It belongs to the class of medications known as cardioselective beta blockers, which preferentially block the beta-1 receptors in the heart rather than the non-selective beta receptors in other parts of the body. As a result, acebutolol can help lower blood pressure, slow heart rate, and improve symptoms associated with angina.

What is Acebutolol used for?

Acebutolol is a beta-1 adrenergic receptor blocker, also classified as a selective β-blocker. It belongs to the class of medications known as cardioselective beta blockers. This category of drugs primarily targets the heart’s beta receptors, reducing the heart rate and myocardial contractility without significantly affecting the blood vessels’ alpha receptors.

In clinical practice, acebutolol is used to treat hypertension (high blood pressure), angina pectoris (chest pain due to coronary artery disease), arrhythmias (abnormal heart rhythms), and sometimes in conjunction with other medications for congestive heart failure management. It functions by blocking the beta-1 receptors on the heart, thus reducing cardiac output and lowering peripheral resistance.

Acebutolol has also been reported to have intrinsic sympathomimetic activity (ISA), a property that contributes to its unique pharmacological profile, potentially affecting its efficacy in treating certain cardiovascular conditions. As with other β-blockers, patients should be aware of their side effects, which can include bradycardia (slow heart rate), hypotension (low blood pressure), and changes in the body’s metabolic functions due to reduced adrenergic activity.

Acebutolol side effects

  1. Bradycardia
  2. Hypotension
  3. Respiratory distress
  4. Gastrointestinal disturbances
  5. Dizziness
  6. Headache
  7. Nausea and vomiting
  8. Diarrhea or abdominal pain
  9. Allergic reactions (rash, itching)
  10. Angina-like symptoms
  11. Fatigue
  12. Weakness

Disclaimer

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