What is Amantadine?
Amantadine is an antiviral medication used to treat and prevent influenza A virus infections. It belongs to the class of adamantane derivatives and works by inhibiting viral replication within the host cells. Amantadine has been shown to be effective in preventing flu-like symptoms when taken as a prophylactic measure, but its use has declined due to widespread resistance among influenza viruses. In addition to its antiviral properties, amantadine is also used off-label for Parkinson’s disease treatment and for managing neurologic and extrapyramidal side effects associated with antipsychotic medications.
What is Amantadine used for?
Amantadine is an antiviral medication that belongs to the class of adamantanes. It was first introduced in 1963 as a treatment for influenza A virus infections, particularly H2N2 subtype. Initially, amantadine was considered a breakthrough drug due to its ability to prevent and treat viral respiratory illnesses. However, over the years, its use has been limited by reports of widespread resistance among certain strains of the influenza virus.
Despite its reduced effectiveness against seasonal flu, amantadine remains a valuable medication for other conditions such as Parkinson’s disease. It acts as a dopamine agonist, modulating neurotransmitter activity in the brain and facilitating muscle control. Amantadine also exhibits mild n-methyl-D-aspartate (NMDA) receptor antagonist properties, which contributes to its therapeutic effects in patients with neurodegenerative disorders. The unique mechanism of action of amantadine has led to its investigation as a treatment for various neurological conditions beyond Parkinson’s disease.
Amantadine side effects
• Anxiety • Dizziness • Confusion • Constipation • Cough • Depression • Dry mouth • Fatigue • Flushing • Hallucinations • Insomnia • Lightheadedness • Nausea • Personality changes • Psychotic episodes • Seizures • Stomach pain • Suicidal thoughts • Tremors • Unusual dreams
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