What is Amlodipine-azilsartan?
Amlodipine-azilsartan, also known as Edarbi, is a fixed-dose combination of two antihypertensive drugs. Amlodipine belongs to the class of calcium channel blockers, which help relax blood vessels and lower blood pressure. Azilsartan, on the other hand, is an angiotensin II receptor antagonist that also helps reduce blood pressure by blocking the action of a natural chemical that narrows blood vessels. The combination of these two drugs in Amlodipine-azilsartan works together to help control high blood pressure and prevent its complications in patients with hypertension.
What is Amlodipine-azilsartan used for?
Amlodipine-azilsartan, also known as Azor, is an antihypertensive medication that belongs to the class of calcium channel blockers and angiotensin II receptor antagonists. It is a combination product, which means it contains two active ingredients: amlodipine besylate and azilsartan medoxomil.
The introduction of amlodipine-azilsartan was made with the aim of providing a more convenient option for patients who require treatment for high blood pressure. The medication works by relaxing blood vessels, allowing blood to flow more easily through them, thereby lowering blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into vascular smooth muscle cells, leading to vasodilation and reduced peripheral resistance.
Azilsartan medoxomil, an angiotensin II receptor antagonist, blocks the effects of angiotensin II, a potent vasoconstrictor. By blocking this pathway, azilsartan helps to reduce blood pressure by decreasing systemic vascular resistance. The combination of these two mechanisms makes amlodipine-azilsartan a suitable treatment option for patients with hypertension, particularly those who are not adequately controlled with monotherapy or require more than one medication to achieve their target blood pressure.
Amlodipine-azilsartan is available in various formulations, including tablets and oral suspensions. It can be taken once daily, usually with or without food, as directed by a healthcare professional. As with any medication, patients should be aware of potential side effects, such as edema, headache, and dizziness, which may occur with the use of amlodipine-azilsartan. Regular monitoring and dose adjustments may be necessary to achieve optimal blood pressure control while minimizing adverse effects.
Amlodipine-azilsartan side effects
- Dizziness
- Headache
- Cough
- Muscle cramps
- Joint pain
- Abdominal pain
- Nausea and vomiting
- Diarrhea
- Fatigue
- Swelling in hands or feet
- High blood potassium levels (hyperkalemia)
- Increased creatinine
- Increased liver enzymes
- Decreased hematocrit
- Hypotension
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