What is Amlodipine-bumetanide?
Amlodipine-bumetanide is a fixed-dose combination medication used to treat high blood pressure (hypertension) and heart failure. Amlodipine, an calcium channel blocker, works by relaxing blood vessels, allowing blood to flow more easily and reducing the amount of work the heart must do. Bumetanide, a loop diuretic, helps remove excess water and salt from the body, further lowering blood pressure and relieving fluid buildup in patients with congestive heart failure.
What is Amlodipine-bumetanide used for?
Amlodipine-bumetanide, also known as Amturnide, is an oral combination medication used to treat high blood pressure (hypertension). It belongs to the class of calcium channel blockers and potassium-sparing diuretics. The fixed-dose combination of amlodipine besylate and bumetanide provides an effective management option for patients with hypertension.
Amlodipine, the first component, works by inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscles through voltage-sensitive channels. This action results in vasodilation and reduced peripheral resistance, thereby lowering blood pressure. Bumetanide, on the other hand, is a potassium-sparing diuretic that promotes the excretion of sodium, chloride, and water from the body while conserving potassium ions. The combination of these two mechanisms makes Amlodipine-bumetanide an effective treatment option for patients with hypertension, particularly those who are resistant to monotherapy or have comorbidities such as heart failure or chronic kidney disease.
Amlodipine-bumetanide side effects
- Dizziness
- Headache
- Lightheadedness
- Flushing
- Nausea
- Vomiting
- Diarrhea
- Stomach pain
- Muscle cramps
- Weakness
- Fatigue
- Rash
- Itching
- Swelling of hands and feet
- Changes in urine output
- Increased blood sugar levels
- Weight gain
- Sleep disturbances
- Anxiety
- Depression
- Insomnia
- Memory problems
- Difficulty concentrating
- Taste changes
- Abnormal heartbeat
- Low blood pressure (hypotension)
- High blood pressure (hypertension) (rarely, in some cases, high blood pressure can occur as a result of taking this medication)
Common side effects:
- Swelling in your legs and feet
- Fatigue
- Headache
Less common side effects:
- Allergic reactions (hives, itching)
- Abnormal kidney function tests
- Changes in liver enzymes
- Increased levels of certain blood components
Disclaimer
The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.