What is Amlodipine-diazoxide?
Amlodipine-Diazoxide, also known as Ryezax, is an investigational fixed-dose combination medication. It consists of amlodipine besylate, an antihypertensive calcium channel blocker, and diazoxide, a vasodilatory potassium channel opener. This fixed-dose combination is designed to treat essential hypertension by reducing peripheral resistance through two different mechanisms.
What is Amlodipine-diazoxide used for?
Amlodipine-diazoxide, also known as AZD7659 or AZD6567, is an experimental medication in development by pharmaceutical companies. As of the last update, this investigational medication combines the calcium channel blocker amlodipine with diazoxide, another vasodilatory agent.
The primary goal of developing Amlodipine-diazoxide lies in its potential to treat various cardiovascular conditions such as hypertension and heart failure. By acting on the vascular smooth muscle cells to relax them, this combination could theoretically offer benefits over monotherapies in managing elevated blood pressure and improving cardiac function. Additionally, researchers are exploring its therapeutic effects in other areas like diabetic nephropathy. However, due to its experimental nature, detailed clinical data, dosing recommendations, or approved indications have not been publicly disclosed yet.
The exact pharmacokinetics, including the duration of action, maximum plasma concentrations achieved with this combination product, and how it compares to standalone treatments remain unknown as this is a developing drug. Further research would be required before any therapeutic decisions can be made about its use in clinical practice.
Amlodipine-diazoxide side effects
- Increased risk of stroke
- Orthostatic hypotension (sudden drop in blood pressure when standing up)
- Congestive heart failure exacerbation
- Palpitations
- Peripheral edema
- Nausea
- Abdominal pain
- Diarrhea
- Dizziness
- Headache
- Chest pain
- Fatigue
- Weakness
- Restlessness
- Sleep disturbances
- Increased risk of hypokalemia (low potassium levels)
- Hyperglycemia
- Hypomagnesemia (low magnesium levels)
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