What is Amlodipine-diltiazem?
Diovan HCT (a brand name for the combination) contains Amlodipine-bisoprolol and not Amlodipine-Diltiazem. However, it seems like you’re looking for a combination of Amlodipine and Diltiazem. If that’s correct, then:
Amlodipine is a calcium channel blocker used to treat high blood pressure and angina. It works by relaxing the muscles around the heart and its arteries.
Diltiazem is also a calcium channel blocker, but it primarily targets the cardiac muscle. It helps slow down certain heart rates or control chest pain in people with angina.
If taken together (Amlodipine-Diltiazem), this combination can help manage high blood pressure and control chest pain by lowering the heart rate and relaxing the muscles around the heart and arteries.
What is Amlodipine-diltiazem used for?
Amlodipine-Diltiazem, also known as Teczem, is a fixed-dose combination medication used in the management of hypertension and angina pectoris. This antihypertensive agent contains a combination of two calcium channel blockers: Amlodipine besylate and Diltiazem hydrochloride.
Amlodipine, the first component of this fixed-dose combination, belongs to the dihydropyridine class of calcium channel blockers. It works by selectively inhibiting the L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and subsequently reducing peripheral resistance and blood pressure. Amlodipine has been extensively used as a monotherapy or in combination with other antihypertensive agents for the treatment of hypertension.
The second component, Diltiazem, is a benzothiazepine derivative that also exerts its effects by inhibiting calcium channels in vascular smooth muscle cells and the heart. However, unlike Amlodipine, it affects both L-type and T-type calcium channels. This dual effect contributes to Diltiazem’s vasodilatory properties and potential benefits in patients with hypertension or angina pectoris. By combining Amlodipine and Diltiazem, the Amlodipine-Diltiazem fixed-dose combination offers a novel therapeutic approach for managing cardiovascular conditions by synergistically enhancing vasodilation.
As a medication, Amlodipine-Diltiazem is available in various formulations, including tablets or capsules. The dosage regimen typically involves once-daily administration, starting with the lowest recommended dose and adjusting as needed to achieve optimal blood pressure control while minimizing adverse effects.
Amlodipine-diltiazem side effects
- Dizziness
- Headache
- Lightheadedness
- Flushing
- Palpitations
- Chest pain
- Swelling in hands or feet
- Constipation
- Diarrhea
- Nausea
- Stomach pain
- Muscle weakness
- Back pain
- Abnormal heart rhythms
- Increased blood uria
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