What is Amlodipine-doxazosin?
Amlodipine-doxazosin is a fixed-dose combination medication composed of Amlodipine, a calcium channel blocker used to treat hypertension and angina, and Doxazosin, an alpha-1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia and high blood pressure. This combination product is intended for the treatment of hypertension in adults.
What is Amlodipine-doxazosin used for?
Amlodipine-doxazosin, also known as Caduet or Nexofenad, is not an actual combination medication that I am aware of. However, Amlodipine and Doxazosin are two separate medications that may be prescribed together in certain clinical situations.
Amlodipine (Calcium Channel Blocker)
Amlodipine is a prescription medication that belongs to the class of calcium channel blockers. It works by relaxing blood vessels, allowing blood to flow more easily and reducing blood pressure and heart rate. Amlodipine is used to treat high blood pressure (hypertension) and certain types of chest pain (angina). As a dihydropyridine calcium channel blocker, Amlodipine has a long half-life, which enables once-daily dosing.
Doxazosin (Alpha-1 Adrenergic Receptor Blocker)
Doxazosin is an alpha-1 adrenergic receptor blocker used primarily to treat benign prostatic hyperplasia (BPH) and high blood pressure. It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Doxazosin also helps lower blood pressure by blocking alpha-1 receptors in the blood vessels.
Clinical Implications of Combined Use
While Amlodipine and Doxazosin are both prescribed for hypertension, their mechanisms of action differ. Amlodipine primarily lowers blood pressure through vasodilation, whereas Doxazosin exerts its effect by blocking alpha-1 receptors in the vascular smooth muscle. Combining these medications may offer additional benefits, such as improved blood flow and reduced risk of cardiovascular events. However, healthcare providers must consider potential side effects and interactions when prescribing Amlodipine with Doxazosin.
Amlodipine-doxazosin side effects
• Hypotension • Dizziness • Headache • Fatigue • Muscle weakness • Nausea • Vomiting • Diarrhea • Abdominal pain • Rash • Itching • Swelling of the face, lips, tongue, or throat (angioedema) • Low blood pressure • Increased risk of falls • Priapism • Impotence • Urinary retention • Orthostatic hypotension
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