What is Amlodipine-enalapril?
Amlodipine-Enalapril, also known as a fixed-dose combination of Amlodipine and Enalapril, is an antihypertensive medication used to treat high blood pressure (hypertension) in adults. It works by relaxing the blood vessels and reducing the heart’s workload, thereby lowering blood pressure. Amlodipine is a calcium channel blocker that inhibits the entry of calcium ions into cardiac muscle and vascular smooth muscle cells, resulting in vasodilation. Enalapril, on the other hand, is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure further. The combination of Amlodipine and Enalapril is designed to provide additive effects in lowering blood pressure while minimizing potential side effects associated with each drug when used alone.
What is Amlodipine-enalapril used for?
Amlodipine and enalapril are two antihypertensive medications that have been combined in fixed-dose combinations, such as Amlodipine-Enalapril.
Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart. By doing so, it helps lower high blood pressure and alleviate symptoms of angina (chest pain) in patients with coronary artery disease.
Enalapril, on the other hand, is a medication classified as an ACE inhibitor. Its mechanism involves preventing the conversion of angiotensin I to angiotensin II, which results in vasodilation and a decrease in blood pressure. Additionally, enalapril has been shown to reduce the production of aldosterone, a hormone that can increase fluid retention, thereby lowering blood pressure.
Amlodipine-Enalapril is indicated for the treatment of high blood pressure (hypertension) and chronic stable angina pectoris in patients not controlled by monotherapy. It has also been prescribed off-label for various conditions such as heart failure, left ventricular hypertrophy, and Raynaud’s disease.
Amlodipine-enalapril side effects
- Dizziness
- Headache
- Coughing up blood or vomit that looks like coffee grounds (indicating bleeding in the stomach)
- Increased urination or more frequent need to urinate
- Muscle cramps
- Nausea or vomiting
- Fatigue
- Painful, swollen, or red tongue
- High potassium levels in the blood
- Edema (swelling) of legs, ankles, and feet
- Low blood pressure (hypotension)
- Fast heart rate (tachycardia)
- Muscle weakness
- Diarrhea
- Abdominal pain
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