What is Amlodipine-guanfacine?
Kimbria is a fixed-dose combination of Amlodipine (a calcium channel blocker) and Guanfacine (an alpha-2 adrenergic agonist), used in the treatment of hypertension and attention deficit hyperactivity disorder (ADHD). This medication combines the vasodilatory effects of Amlodipine with the central nervous system actions of Guanfacine to provide a dual-action therapy.
What is Amlodipine-guanfacine used for?
Amlodipine-guanfacine, also known as Intuniv, is an extended-release medication that combines the benefits of two distinct classes of medications: a calcium channel blocker (amlodipine) and an alpha-2 adrenergic agonist (guanfacine). Amlodipine is primarily used to treat high blood pressure by relaxing the blood vessels, allowing for easier flow of blood and consequently reducing blood pressure. Guanfacine, on the other hand, works by stimulating alpha-2 receptors in the brain, which can help reduce excessive activity of neurons and lead to decreased impulsivity and anxiety symptoms.
The combination of amlodipine and guanfacine in Intuniv provides a unique therapeutic profile for managing attention deficit hyperactivity disorder (ADHD) symptoms. Specifically, Intuniv is approved by the US FDA for the treatment of ADHD in pediatric patients aged 6-12 years old and adolescent patients 13-16 years old who are not adequately controlled with standard ADHD treatments. By combining the vaso-relaxing properties of amlodipine with the neuronal stabilizing effects of guanfacine, Intuniv can provide an additional treatment option for individuals with ADHD who require more targeted symptom management.
Amlodipine-guanfacine side effects
- Allergic reactions (such as swelling, redness, or hives)
- Changes in heart rate
- Chest pain
- Constipation
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dry mouth
- Edema (swelling of hands, feet, or face)
- Fatigue
- Headache
- High blood pressure
- Increased appetite
- Insomnia
- Irritability
- Memory problems
- Muscle weakness
- Nausea
- Pain in the back, legs, or joints
- Redness of eyes
- Shortness of breath
- Sleepiness
- Stomach upset
- Tremors
- Vision changes
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