What is Amlodipine-moxonidine?
Amlodipine-moxonidine is a combination of two medications used to manage high blood pressure (hypertension). Each drug works differently to lower blood pressure:
Amlodipine: A calcium channel blocker that relaxes and widens blood vessels, improving blood flow and reducing the workload on the heart.
Moxonidine: An imidazoline receptor agonist that helps lower blood pressure by affecting the central nervous system to reduce nerve signals that tighten blood vessels.
Together, they can be more effective in reducing blood pressure than either medication alone.
What is Amlodipine-moxonidine used for?
Amlodipine-Moxonidine is an investigational medication that combines the calcium channel blocker Amlodipine with the centrally acting antihypertensive agent Moxonidine. Amlodipine, a well-established antihypertensive drug, works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscles, leading to vasodilation and decreased blood pressure.
Moxonidine, on the other hand, acts centrally as an imidazoline receptor agonist to decrease sympathetic nervous system activity, resulting in decreased peripheral resistance and reduced blood pressure. The combination of Amlodipine-Moxonidine aims to provide a synergistic effect by targeting multiple mechanisms for lowering blood pressure. This novel therapeutic approach may offer enhanced efficacy in managing hypertension compared to either agent alone.
Amlodipine-moxonidine side effects
• Dizziness • Headache • Fatigue • Sleepiness (sedation) • Diarrhea • Stomach upset • Cough • Upper respiratory tract infection • Increased risk of developing new diabetes or worsening existing diabetes • High blood sugar • Hypotension (low blood pressure) • Orthostatic hypotension (dizziness due to sudden drop in blood pressure when standing up) • Edema (swelling in feet, ankles, and hands) • Rash • Itching • Muscle weakness • Abdominal pain
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