What is Amlodipine-perindopril?
Amlodipine-Perindopril (Co-Amrix) is an antihypertensive combination medication containing Amlodipine, a calcium channel blocker, and Perindopril, an angiotensin-converting enzyme inhibitor (ACE inhibitor). This fixed-dose combination is used to treat high blood pressure in adults. Amlodipine helps relax blood vessels to improve blood flow, while Perindopril reduces the production of certain hormones that constrict blood vessels. The combination of these two medications works synergistically to effectively lower blood pressure and prevent its complications.
What is Amlodipine-perindopril used for?
Amlodipine-Perindopril, also known as Amloper or Coversyl-10, is a fixed-dose combination medication that combines the calcium channel blocker amlodipine with the angiotensin-converting enzyme (ACE) inhibitor perindopril. This dual-action combination allows for simultaneous lowering of blood pressure and management of hypertension.
Amlodipine, as part of this formulation, works by relaxing the muscles around blood vessels, thereby reducing their resistance to blood flow, and consequently lower blood pressure. Perindopril, on the other hand, inhibits the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure, thus lowering it. The combination of these two active ingredients provides an additive effect in reducing blood pressure.
Amlodipine-Perindopril is used in the management of high blood pressure and heart failure in adult patients. The benefits include effective control of hypertension without causing significant adverse effects on renal function or electrolyte balance, compared to monotherapy with either component. However, as with any medication regimen, potential side effects should be weighed against the therapeutic advantages for each patient’s specific clinical profile.
Amlodipine-Perindopril is available in various strengths and forms (e.g., tablets) and its dosing typically depends on the severity of hypertension or heart failure in the individual being treated.
Amlodipine-perindopril side effects
- Cough
- Dizziness
- Fatigue
- Headache
- Muscle weakness
- Rash
- Swelling in hands and feet
- Upper respiratory tract infection
- Abdominal pain
- Decreased urination
- Diarrhea
- Increased urination
- Nausea
- Sore throat
- Stomach upset
- Vomiting
- Anxiety
- Depression
- Sleepiness
- Sweating
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