What is Amlodipine-spironolactone?
Amlodipine-spirolonactone is not typically provided together, however one is the generic form of a calcium channel blocker while the other is a potassium sparing diuretic. However, if referring to “Aldactazide” or “Dyazide”, it would be Aldosterone antagonist Spironolactone combined with Amlodipine.
What is Amlodipine-spironolactone used for?
Amlodipine-spironolactone, also known as Aldo-Card or Duo-Pres, is a fixed-dose combination medication. It consists of two active ingredients: amlodipine, a calcium channel blocker, and spironolactone, an aldosterone antagonist. This combination is specifically designed to manage hypertension (high blood pressure) in adult patients.
The primary mechanism of action for this medication involves the inhibition of vasoconstrictive responses and the antagonism of aldosterone’s effects on the renal sodium-transporting system. Amlodipine works by relaxing vascular smooth muscle, thereby reducing peripheral resistance and decreasing blood pressure. Spironolactone, as an aldosterone receptor antagonist, reduces the levels of sodium in the blood, which also contributes to lowering blood pressure. The dual-action approach can lead to enhanced therapeutic effects compared to monotherapy with either agent alone.
Amlodipine-spironolactone side effects
- Dizziness
- Headache
- Lightheadedness
- Fatigue
- Weakness
- Muscle pain or cramping
- Diarrhea
- Nausea and vomiting
- Abdominal cramps
- Rapid heartbeat
- Palpitations
- Edema (swelling)
- Increased potassium levels
- Decreased sodium levels
- Hypotension (low blood pressure)
- Thirst or increased urination
- Joint pain or swelling
- Muscle weakness or numbness
- Skin rash
- Itching or hives
Disclaimer
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