What is Amlodipine-tolterodine?
Amlodipine is used as an antihypertensive and antianginal drug whereas Tolterodine is primarily utilized to treat overactive bladder symptoms. However, a different fixed-dose combination called Benidipine-hydroxyzine was not approved but another one: “Benazepril-amlodipine-tolterodine” or Benzepril-tolterodine-Amlodipine is available under the name Triamterene-Amlodipine-Tolterodine in the United States.
What is Amlodipine-tolterodine used for?
Amlodipine:
Amlodipine is a prescription calcium channel blocker (CCB) medication primarily used to treat high blood pressure (hypertension) and chest pain or angina. It works by relaxing the muscles in blood vessel walls, allowing for easier blood flow, reduced blood pressure, and increased oxygen supply to the heart. Amlodipine is available in oral tablet form under various brand names, including Norvasc. When used as directed, amlodipine can help reduce the risk of heart attack, stroke, and other cardiovascular events.
As a CCB, amlodipine belongs to a class of medications that target specific ion channels (L-type calcium channels) in the cell membranes surrounding blood vessels. This unique mechanism allows for selective relaxation of these muscle cells, thereby reducing vascular resistance and improving cardiac output. Amlodipine’s effects are generally well-tolerated by most patients, although some individuals may experience mild side effects like edema or dizziness.
Tolterodine:
Tolterodine is an oral medication used to treat overactive bladder (OAB) symptoms in adults, including urgency, frequency, and incontinence. It belongs to the muscarinic receptor antagonist class of medications, which work by blocking certain nerve receptors (M3 receptors) responsible for contractions of the bladder muscles. By inhibiting these receptors, tolterodine reduces spasmodic contractions, allowing patients with OAB to empty their bladders more efficiently and comfortably.
When used as directed, tolterodine has been shown to significantly reduce symptoms associated with overactive bladder, improving quality of life for millions worldwide. Tolterodine is available in oral tablet form under various brand names, including Detrol and Detrusitol. Common side effects are generally mild to moderate, affecting a minority of users.
Amlodipine-tolterodine side effects
- Dizziness
- Lightheadedness
- Headache
- Stomach pain
- Abdominal cramps
- Diarrhea
- Nausea and vomiting
- Flushing
- Fatigue
- Weakness
- Palpitations
- Increased sweating
- Cold sweats
- Muscle aches
- Joint pain
- Changes in taste or smell
- Dry mouth
- Abnormal heart rhythms
- Rapid heartbeat
- Chest pain
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