What is Anacetrapib?
Anacetrapib is an experimental cholesterol-raising agent that acts as a cholesterol ester transfer protein (CETP) inhibitor. It is being investigated for the potential to raise high-density lipoprotein (HDL), or “good,” cholesterol levels and decrease low-density lipoprotein (LDL), or “bad,” cholesterol levels in patients with cardiovascular disease. Anacetrapib was previously under development by Merck & Co. but its clinical trials were halted due to liver toxicity concerns.
What is Anacetrapib used for?
Anacetrapib is an experimental cholesterol-lowering medication that was being developed by GlaxoSmithKline (GSK) to treat patients with high cardiovascular risk. It works by inhibiting the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9), which plays a key role in regulating low-density lipoprotein (LDL) cholesterol levels in the bloodstream. By blocking PCSK9, anacetrapib reduces LDL cholesterol production and increases its clearance from the blood, thereby helping to lower cholesterol levels.
Anacetrapib was investigated as a potential treatment for patients at high risk of cardiovascular events, such as those with established cardiovascular disease or multiple cardiovascular risk factors. The drug showed promise in early-stage clinical trials by significantly lowering LDL cholesterol levels, but its development was halted due to concerns regarding the cardiovascular safety profile. Despite this setback, anacetrapib may still have therapeutic applications in certain contexts, and ongoing research continues to explore its potential benefits.
Anacetrapib side effects
- Edema
- Increased creatinine levels
- Back pain
- Nausea
- Diarrhea
- Fatigue
- Headache
- Muscle spasm
- Cough
- Pain in extremity
- Decreased appetite
- Abdominal discomfort
- Upper respiratory tract infection
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