What is Avandaryl-rosiglitazone?
Avandaryl (rosiglitazone) is an oral antidiabetic medication used in the treatment of type 2 diabetes mellitus. It belongs to the class of thiazolidinediones, which work by activating peroxisome proliferator-activated receptor gamma (PPARγ), thereby enhancing insulin sensitivity and glucose utilization in the body. Avandaryl improves glycemic control and helps reduce blood sugar levels, with common dosage forms including tablets.
What is Avandaryl-rosiglitazone used for?
Avandaryl (also known as Rosiglitazone) is an oral antidiabetic agent belonging to the thiazolidinedione class. It was initially approved by the US FDA in 1999 under the brand name Avandia for the treatment of type 2 diabetes mellitus.
The primary mechanism of action of rosiglitazone involves activating peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that regulates glucose and lipid metabolism. By binding to PPARγ, rosiglitazone enhances insulin sensitivity in peripheral tissues, thereby facilitating the uptake of glucose by cells and reducing blood glucose levels.
In clinical practice, Avandaryl is commonly used as monotherapy or combination therapy with other antidiabetic agents (such as metformin) for managing type 2 diabetes. It works synergistically with these drugs to improve glycemic control in patients who have failed to achieve adequate control with monotherapy alone.
Avandaryl-rosiglitazone side effects
- Hypoglycemia
- Headache
- Upper respiratory tract infection
- Dizziness
- Flu syndrome
- Pharyngitis
- Sinusitis
- Nausea
- Diarrhea
- Muscle pain
- Fatigue
- Sleep disturbance
- Arthritis
- Increased risk of heart failure (in patients with NYHA Class III or IV cardiac status)
- Increased risk of cardiovascular events (such as MI, stroke, and death due to CV causes) in patients with established CV disease or multiple risk factors for CV disease
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