What is Azilsartan-hydrochlorothiazide?
Azilsartan-Hydrochlorothiazide is an oral antihypertensive combination medication. It contains the active ingredients azilsartan, a direct renin inhibitor, and hydrochlorothiazide (HCTZ), a thiazide diuretic. Azilsartan works by inhibiting renin, preventing the formation of angiotensin II, and thereby reducing vasoconstriction. HCTZ promotes water excretion through its diuretic effects. Together, they help lower blood pressure in patients with hypertension.
What is Azilsartan-hydrochlorothiazide used for?
Azilsartan-hydrochlorothiazide, commonly known as Edarbi HCT, is an oral antihypertensive medication. It combines two active ingredients: azilsartan and hydrochlorothiazide. Azilsartan belongs to the class of angiotensin II receptor antagonists (ARBs), which inhibit the effects of angiotensin II on blood vessels, thereby reducing vasoconstriction and decreasing blood pressure. On the other hand, hydrochlorothiazide is a thiazide diuretic that promotes the excretion of sodium and chloride ions from the body, also leading to decreased fluid volume in the circulatory system.
Mechanism of Action
As an ARB, azilsartan blocks the action of angiotensin II on its receptors in the blood vessels, causing vasodilation (widening of the blood vessels). This reduction in peripheral resistance leads to a decrease in blood pressure. In contrast, hydrochlorothiazide works by inhibiting sodium reabsorption in the distal convoluted tubule and cortical collecting ducts of the kidneys. By promoting diuresis (excretion of urine), it helps reduce blood volume and alleviate blood pressure levels. The dual-action mechanism of azilsartan-hydrochlorothiazide makes it an effective treatment for hypertension, especially in patients who have not responded to monotherapy.
Indications
Azilsartan-hydrochlorothiazide is indicated for the treatment of essential hypertension (high blood pressure). It is typically prescribed as a once-daily oral medication for patients with mild to moderate hypertension. However, it’s essential to consult a healthcare professional or pharmacist for accurate dosing and regimen, as this may vary depending on individual patient characteristics.
Azilsartan-hydrochlorothiazide side effects
• Diarrhea • Headache • Fatigue • Dizziness • Stomach pain • Nausea • Vomiting • Cough • Chest pain • Abnormal heart rhythms • High blood pressure (may be masked) • Muscle cramps • Joint pain • Weakness • Loss of appetite • Weight loss • Increased urine output • Urine retention • Altered sense of taste • Rash • Itching • Hair loss
Disclaimer
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