What is Aztreonam?
Aztreonam is a bacteriocidal agent that belongs to the class of monobactam antibiotics. It works by inhibiting bacterial cell wall synthesis, thereby exerting its antibacterial effect. Aztreonam is effective against gram-negative bacteria and some gram-positive bacteria, including those resistant to other beta-lactams. It is administered intravenously or intramuscularly for the treatment of various bacterial infections such as pneumonia, sepsis, and skin and soft tissue infections.
What is Aztreonam used for?
Aztreonam is a synthetic bactericidal antibiotic that belongs to the monobactam class of antibiotics. It was approved by the US FDA in 1988 for the treatment of various bacterial infections, including those caused by susceptible Gram-negative bacteria such as Pseudomonas aeruginosa and other strains. Aztreonam works by inhibiting cell wall synthesis in bacteria, ultimately leading to their death. This mechanism of action allows it to be effective against a wide range of Gram-negative bacteria that are resistant to other antibiotics.
Aztreonam is typically administered intravenously or as an injection, often in combination with other medications, and its effects can be seen within 1-3 hours of administration. The antibiotic has a relatively long half-life of approximately 2 hours, allowing for less frequent dosing compared to other antibiotics. Its use is generally reserved for patients who have not responded well to other treatments or have specific allergies to other antibiotics in the beta-lactam class. Aztreonam’s efficacy and safety profile make it a valuable option for managing infections caused by Gram-negative bacteria that are resistant to more conventional therapies.
Aztreonam side effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Allergic reactions (rare)
- Anemia
- Elevated liver enzymes
- Hives
- Itching
- Swelling of face, lips, tongue or throat (anaphylaxis)
- Seizure
- Renal impairment in patients with pre-existing kidney problems
Disclaimer
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