What is Bedaquiline?
Bedaquiline is an anti-tuberculosis medication used in the treatment of multidrug-resistant tuberculosis (MDR-TB). It works by inhibiting the enzyme ATP synthase, which is essential for the growth and survival of Mycobacterium tuberculosis. Bedaquiline is typically administered orally once daily for 14 days to newly diagnosed patients with MDR-TB or for up to 1 year in previously treated patients who have failed previous therapies. It has been shown to improve treatment outcomes and reduce mortality rates among patients with MDR-TB.
What is Bedaquiline used for?
Bedaquiline, also known as Sirturo, is an antibiotic medication used to treat multi-drug resistant tuberculosis (MDR-TB). It was approved by the US FDA in 2012 and has been adopted by many countries as a second-line treatment for MDR-TB. Bedaquiline is particularly effective against Mycobacterium tuberculosis, the bacterium that causes TB.
As an antibiotic, bedaquiline works by targeting the bacteria that cause MDR-TB and inhibiting their ability to replicate. It specifically targets the proton pump in the bacterial cell wall, which is essential for energy production in the bacteria. By preventing energy production, bedaquiline effectively kills the bacteria, helping to clear the infection. However, due to its mechanism of action, there have been reports of acquired drug resistance with prolonged use or incorrect dosing. As such, strict adherence to treatment regimens and close monitoring are crucial when administering bedaquiline for MDR-TB therapy.
Bedaquiline side effects
- Abnormal heart rhythm
- Allergic reaction
- Anxiety
- Bleeding
- Chest pain or discomfort
- Confusion
- Dizziness
- Feeling of unusual tiredness
- Hallucinations
- Increased risk of suicidal thoughts or behaviors
- Nausea and vomiting
- Sleepiness
- Swelling in the legs, ankles, feet
- Vision changes
- Weakness
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