Bisoprolol-hydrochlorothiazide

What is Bisoprolol-hydrochlorothiazide?

Bisoprolol-hydrochlorothiazide is a fixed-dose combination medication consisting of bisoprolol, a beta-1 selective adrenergic receptor blocker, and hydrochlorothiazide, a thiazide diuretic. It is used to treat hypertension (high blood pressure) in adults by reducing blood pressure through its vasodilatory effect on the cardiovascular system. This combination therapy is often prescribed for patients with stage 2 hypertension or those who have been non-responsive to monotherapy alone.

What is Bisoprolol-hydrochlorothiazide used for?

Bisoprolol-fumarate (not hydrochlorothiazide, but we’ll consider the equivalent combination) is an oral medication used in the management of hypertension and heart failure. It belongs to a class of drugs known as beta blockers. As a beta blocker, bisoprolol works by inhibiting the action of epinephrine and norepinephrine on beta receptors, thereby reducing heart rate, myocardial contractility, and cardiac output.

In combination with hydrochlorothiazide (HCTZ), a thiazide diuretic, the medication is designed to provide synergistic effects in managing hypertension. The HCTZ component helps reduce fluid volume by increasing urine production, further lowering blood pressure. This combination of bisoprolol-fumarate and HCTZ can be effective in patients with essential hypertension or heart failure when used under medical supervision.

When administered as directed, this drug class is known for its ability to reduce the risk of cardiovascular events such as myocardial infarction, stroke, and cardiac arrhythmias. The combination therapy may offer a benefit in terms of better blood pressure control compared to either agent alone.

Bisoprolol-hydrochlorothiazide side effects

• Edema • Asthenia (weakness) • Coughing • Dizziness • Headache • Palpitations • Rash • Sinusitis • Somnolence (drowsiness) • Sweating • Vomiting • Allergic reaction • Back pain • Chest pain • Dyspepsia (indigestion) • Electrolyte imbalance • Muscle cramp • Muscle weakness • Photosensitivity (skin reaction to sunlight) • Skin ulcer


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