What is Canagliflozin-dapagliflozin?
Xultophy is a medication that combines two diabetes medications: insulin degludec and liraglutide. This dual-chamber injection contains a long-acting basal insulin and an analog of glucagon-like peptide-1 (GLP-1) receptor agonist, which helps to regulate blood sugar levels by stimulating insulin secretion and inhibiting glucagon release. Xultophy is used in the management of type 2 diabetes.
What is Canagliflozin-dapagliflozin used for?
Name: Xultophy; also known as dual SGLT-1 and -2 inhibitor (sodium-glucose cotransporter).
Xultophy is a dual-action anti-diabetic medication designed to help individuals manage high blood sugar levels associated with type 2 diabetes. It belongs to the class of drugs known as sodium-glucose cotransporter inhibitors, specifically targeting both SGLT-1 and SGLT-2 receptors in the intestines and kidneys, respectively.
The medication functions by inhibiting these receptors, which are responsible for reabsorbing glucose from the gut back into the bloodstream. By blocking these transporters, Xultophy increases the amount of glucose excreted through urine, thereby reducing blood sugar levels. Additionally, its mechanism also promotes mild diuresis and reduces body weight.
Xultophy can be administered via injection once-daily to patients with type 2 diabetes, particularly those who are unable or unwilling to take oral medications.
Canagliflozin-dapagliflozin side effects
- Hypotension
- Headache
- Diarrhea
- Nausea
- Vomiting
- Dizziness
- Lightheadedness
- Injection site reactions (with injectable form)
- Increased risk of amputations, especially of the toes
- Genital infections in women (yeast vaginitis or vulvovaginal candidiasis)
- Blurred vision
- Joint pain and swelling (arthralgia/arthritis-like symptoms)
- Muscle weakness
- Increased risk of bladder cancer
- Urinary tract infection
- Thirst
- Increased blood sugar levels despite treatment (hyperglycemia)
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