What is Candesartan-amlodipine?
“Candesartan-amlodipine, marketed under the brand names Atacand Plus and Candesarta AMLO among others, is a fixed-dose combination of an angiotensin II receptor antagonist (candesartan) and a calcium channel blocker (amlodipine). This medication is used to treat high blood pressure and heart failure by relaxing blood vessels, thereby reducing blood pressure.”
What is Candesartan-amlodipine used for?
Name: Candesartan Amlodipine
Classification and Action: Candesartan amlodipine is a fixed-dose combination medication that belongs to the class of antihypertensive agents known as angiotensin II receptor blockers (ARBs) in conjunction with calcium channel blockers (CCBs). The candesartan component exerts its effects by selectively blocking the binding of angiotensin II to its receptor, leading to vasodilation and a subsequent decrease in blood pressure. Meanwhile, the amlodipine component works as a CCB, primarily through the inhibition of the L-type calcium channels on smooth muscle cells within the arterial walls, ultimately resulting in relaxation of these tissues and decreased peripheral resistance.
Therapeutic Use: This drug is used for the treatment of hypertension (high blood pressure) in adult patients. By combining two distinct mechanisms of action, candesartan amlodipine offers a dual approach to managing elevated blood pressure levels. The therapy aims to achieve a balance between lowering the blood pressure and minimizing adverse effects that may be associated with single-agent therapy. The medication’s role in managing hypertension can contribute to the reduction of cardiovascular risk factors over time.
Note on Safety: It is essential to consult medical guidance for specific recommendations regarding dosing, potential side effects, drug interactions, and any contraindications when prescribing candesartan amlodipine for patients.
Candesartan-amlodipine side effects
- Headache
- Dizziness
- Edema (swelling)
- Cough
- Fatigue
- Nausea and vomiting
- Abdominal pain
- Diarrhea or constipation
- Insomnia or sleep disturbances
- Increased urination or thirst
- Muscle cramps or spasms
- Joint pain or inflammation
- Sinusitis or respiratory infections
- Skin rash, itching, or lesions
- Decreased kidney function
- Hypotension (low blood pressure)
- Hyperkalemia (high potassium levels)
- Increased liver enzymes
- Weight gain or loss
- Flu-like symptoms
- Increased blood sugar
- Bone pain
- Swelling of the legs and feet
- Cough with phlegm production
Disclaimer
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