What is Cefaloridine?
Cefaloridine is a first-generation cephalosporin antibiotic, which was the first semi-synthetic beta-lactam antibiotic. It was developed in 1965 and has been used to treat various bacterial infections such as pneumonia, meningitis, and urinary tract infections. Cefaloridine acts by inhibiting cell wall synthesis in bacteria, leading to their death. It is administered intravenously and typically taken every six hours.
What is Cefaloridine used for?
Cefaloridine is an antibiotic medication that belongs to the second-generation cephalosporin class of antibiotics. It was one of the first oral cephalosporins developed and was marketed in the 1960s, primarily used for the treatment of various bacterial infections such as pneumonia, bronchitis, and urinary tract infections.
Cefaloridine works by inhibiting cell wall synthesis in bacteria, ultimately leading to their death. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, although its efficacy may vary depending on the type of infection and susceptibility of the bacterial strain. The typical dosing regimen for cefaloridine involves oral administration of 0.5-1 g every six hours, with adjustments made based on patient age, weight, and renal function.
As a pharmacist, I can inform you that cefaloridine is no longer widely used today due to its relatively low efficacy compared to other cephalosporins and concerns regarding resistance patterns among certain bacteria. Nonetheless, its historical significance as one of the pioneering oral cephalosporins remains noteworthy in the evolution of antibiotic therapy.
Cefaloridine side effects
- Allergic reactions (such as hives, itching, and difficulty breathing)
- Diarrhea
- Vaginitis (infection or inflammation of the vagina)
- Genital pruritus (itching around the genitals)
- Nausea
- Abdominal pain
- Hematuria (blood in the urine)
- Dysuria (painful urination)
- Candidiasis (yeast infection)
- Oral candidiasis (thrush)
- Erythema multiforme (skin rash with blisters and target-shaped lesions)
- Stevens-Johnson syndrome (severe skin reaction with mucous membrane involvement)
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