What is Cefamandole?
Cefamandole is a second-generation cephalosporin antibiotic used to treat various bacterial infections, including skin and soft tissue infections, bone and joint infections, and urinary tract infections. It works by inhibiting the growth of bacteria by interfering with the synthesis of their cell walls. Cefamandole has a broad spectrum of activity against Gram-positive and some Gram-negative bacteria.
What is Cefamandole used for?
Cefamandole is a third-generation cephalosporin antibiotic, which was first introduced in the 1970s. It belongs to the class of beta-lactam antibiotics and works by inhibiting bacterial cell wall synthesis, ultimately leading to cell lysis and death. Cefamandole has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, including those that are resistant to other cephalosporins.
Cefamandole is effective against various pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, and Klebsiella pneumoniae. It is also active against some Gram-positive organisms like Staphylococcus aureus, including strains that produce beta-lactamase enzymes. The drug was administered parenterally, either intramuscularly or intravenously, and was available in different formulations for various clinical uses. Although cefamandole was widely used initially, its popularity waned due to the emergence of resistant bacterial strains and the availability of more modern cephalosporin antibiotics with broader spectra of activity and better pharmacokinetic profiles.
Cefamandole side effects
• Abdominal pain • Allergic reactions (rash; hives; itching; difficulty swallowing or breathing; dizziness; lightheadedness) • Anxiety • Bone pain • Chest pain • Diarrhea • Fatigue • Fever • Hiccups • Nausea • Skin rash • Throat tightness
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