What is Cefclidin?
Cefclidin is a newer generation cephalosporin antibiotic that is structurally related to ceftriaxone. It has shown potent activity against a wide range of Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics such as MRSA (methicillin-resistant Staphylococcus aureus) and ESBL-producing Enterobacteriaceae. The drug’s mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), ultimately leading to bacterial cell death.
What is Cefclidin used for?
Cefclidin (INN) is an experimental, broad-spectrum cephalosporin antibiotic
Cefclidin is a newer generation cephalosporin antibiotic that is structurally related to ceftriaxone. It has shown potent activity against a wide range of Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics such as MRSA (methicillin-resistant Staphylococcus aureus) and ESBL-producing Enterobacteriaceae. The drug’s mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), ultimately leading to bacterial cell death.
Pharmacokinetic studies have shown that cefclidin is well-absorbed after oral administration, with a bioavailability of approximately 70%. Its serum half-life is reported to be around 2-3 hours in healthy subjects, allowing for once-daily dosing. Cefclidin has been investigated as a potential treatment for various bacterial infections, including community-acquired pneumonia (CAP), skin and soft tissue infections (SSTIs), and urinary tract infections (UTIs). However, it is essential to note that cefclidin’s clinical efficacy and safety profile are still being evaluated in ongoing studies.
Cefclidin side effects
- Allergic reactions (such as hives, itching, and difficulty breathing)
- Abdominal pain or cramping
- Diarrhea
- Nausea and vomiting
- Headache
- Fatigue
- Dizziness
- Rash or skin irritation
- Muscle weakness
- Joint pain or swelling
- Confusion or changes in mental state
- Seizures (rare)
- Yellowing of the skin and eyes (jaundice)
- Decreased white blood cell count
- Blood clotting disorders
- Stevens-Johnson syndrome (a rare but serious skin condition)
- Toxic epidermal necrolysis (a rare but life-threatening skin condition)
Disclaimer
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