Cefmetazole sodium

What is Cefmetazole sodium?

Cefmetazole sodium is a third-generation cephalosporin antibiotic. It belongs to the beta-lactam class of antibiotics and has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including some beta-lactamase-producing organisms. Cefmetazole sodium is used to treat various bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft tissue infections, and intra-abdominal infections. It works by inhibiting cell wall synthesis in susceptible bacteria, ultimately leading to their death.

What is Cefmetazole sodium used for?

Cefmetazole sodium is a third-generation cephalosporin antibiotic that belongs to the class of beta-lactam antibiotics. It was first introduced in Japan in 1983 under the brand name Astellicin. This medication is used to treat various bacterial infections, particularly those caused by susceptible strains of Gram-positive and Gram-negative bacteria.

The mechanism of action of cefmetazole sodium involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which are essential for the cross-linking of peptidoglycan in bacterial cell walls. This leads to the weakening of the bacterial cell wall, resulting in its eventual lysis and death. Cefmetazole sodium has a broad spectrum of activity, with efficacy against both aerobic and anaerobic bacteria.

As an injectable drug, cefmetazole sodium is administered intravenously or intramuscularly for parenteral use. The medication’s antibacterial activity is based on its ability to inhibit the growth of microorganisms that are susceptible to it, thereby allowing the host’s immune system to take control and recover from infection.

Cefmetazole sodium side effects

  1. Abdominal pain
  2. Allergic reactions (rash, hives)
  3. Confusion
  4. Diarrhea
  5. Dizziness
  6. Fever
  7. Headache
  8. Increased bleeding tendency
  9. Increased liver enzymes
  10. Injection site reaction
  11. Joint pain
  12. Mental/mood changes (depression)
  13. Nausea/vomiting
  14. Rarely, severe allergic reactions leading to anaphylaxis
  15. Stevens-Johnson syndrome
  16. Thrombocytopenia

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