What is Cefonicid?
Cefonicid is a second-generation cephalosporin antibiotic, which falls under the category of beta-lactam antibiotics. It belongs to the ceph-3 (first generation), but has some characteristics similar to second-generation cephalosporins, such as a broad spectrum of activity against both gram-positive and gram-negative bacteria. Cefonicid is administered orally or intravenously, typically for the treatment of various bacterial infections including urinary tract infections, skin infections, and respiratory tract infections. It functions by inhibiting cell wall synthesis in susceptible bacteria, ultimately leading to their death.
What is Cefonicid used for?
Cefonicid, also known as Kefurox or Urocef, is a third-generation cephalosporin antibiotic. It was first introduced in the 1970s for the treatment of various bacterial infections, particularly urinary tract infections (UTIs), pyelonephritis, and skin and soft tissue infections.
Cefonicid belongs to the cephem class of antibiotics, which are broad-spectrum antibacterial agents that inhibit the synthesis of the bacterial cell wall. This mechanism of action is distinct from other classes of antibiotics, such as beta-lactams, which interfere with protein synthesis or bind to essential cellular components. Cefonicid’s third-generation classification suggests it has a narrower spectrum than earlier cephalosporin generations but maintains a good balance between efficacy and safety. Its use in treating UTIs and skin infections stems from its ability to effectively target Gram-negative bacteria, such as Escherichia coli (E. coli), while being generally safe for use in patients with normal renal function.
Cefonicid side effects
- Diarrhea
- Nausea
- Vaginal yeast infection
- Abdominal pain
- Stomach upset
- Blood dyscrasias (rare)
- Allergic reaction (rare)
- Superinfection
- Oral and vaginal candidiasis
- Pseudomembranous colitis
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