What is Ceforanide?
Ceforanide is a third-generation cephalosporin antibiotic that contains the cephem nucleus with a 7-aminocephalosporanic acid (7-ACA) side chain. It has a broad spectrum of activity, including gram-positive and gram-negative bacteria, such as Escherichia coli and Pseudomonas aeruginosa. Ceforanide is typically administered intravenously or orally to treat various bacterial infections, but it is no longer commercially available in many countries due to its replacement by other third-generation cephalosporins with improved pharmacokinetics.
What is Ceforanide used for?
Ceforanide is a broad-spectrum, third-generation cephalosporin antibiotic. It belongs to the class of antibiotics known as cephams, which have a similar structure to penicillin but with modifications that make them more stable and effective. As a result of this structural modification, ceforanide has shown a wider spectrum of activity against various bacterial infections compared to its predecessors.
The mechanism of action of ceforanide is similar to other cephalosporins, which involves the inhibition of cell wall synthesis in bacteria by binding to penicillin-binding proteins (PBPs) present in the bacterial cell wall. This ultimately leads to the disruption of the normal process of peptidoglycan formation and results in the death of the bacterial cells. Ceforanide is administered orally or intravenously, with its pharmacokinetics characterized by a relatively short half-life that requires frequent dosing schedules.
Pharmacological Profile
As a broad-spectrum antibiotic, ceforanide has demonstrated efficacy against both Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. It shows strong activity against species like Escherichia coli (E. coli), Klebsiella pneumoniae, and Staphylococcus aureus, among others. The antimicrobial profile of ceforanide makes it a valuable asset in treating various bacterial infections across different age groups and clinical settings.
Clinical Applications
Due to its pharmacological properties, ceforanide has been employed in the treatment of diverse conditions such as urinary tract infections (UTIs), respiratory tract infections (RTIs), skin and soft tissue infections (SSTIs), and intra-abdominal infections. However, due to specific factors related to its development status as of now, this drug is still being studied extensively for its full therapeutic potential in these clinical scenarios.
Ceforanide side effects
• Abdominal pain • Altered sense of taste • Anxiety • Decreased platelet count • Diarrhea • Dizziness • Elevated liver enzymes • Fatigue • Feeling of burning or warmth in the mouth and throat • Hiccups • Increased salivation • Joint pain • Muscle weakness • Nausea • Skin rash • Tinnitus (ringing, buzzing, or other noises in the ears) • Vaginal itching
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