What is Cefpiramide?
Cefpiramide is a third-generation cephalosporin antibiotic. It works by inhibiting the synthesis of bacterial cell walls, ultimately leading to bacterial cell death. Cefpiramide has been used to treat various infections caused by susceptible bacteria, including those affecting the skin and soft tissue, urinary tract, and respiratory tract. Its pharmacokinetic properties allow for once-daily dosing, which can be beneficial in terms of convenience and compliance. However, the exact usage and efficacy of cefpiramide may vary depending on specific indications, patient populations, and clinical contexts.
What is Cefpiramide used for?
Cefpiramide is a third-generation cephalosporin antibiotic that belongs to the beta-lactam class of drugs. It is a semi-synthetic derivative of cephalexin and has been designed to have broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Cefpiramide works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs) present in the bacterial cell envelope. This leads to weakened bacterial cell walls, ultimately causing cell lysis and death. It has been shown to have potent activity against a wide range of susceptible organisms, including Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae.
Cefpiramide is typically administered parenterally (intramuscularly or intravenously) to treat various bacterial infections such as community-acquired pneumonia, skin and soft tissue infections, urinary tract infections, and septicemia. The efficacy of cefpiramide in these conditions has been demonstrated in several clinical trials, which have shown significant reductions in the number of isolates obtained from patients with cefpiramide treatment compared to those without treatment.
Cefpiramide side effects
- Allergic reactions (rarely)
- Abdominal pain
- Dizziness
- Fever
- Headache
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Flatulence
- Increased salivation
- Taste changes
- Skin rash
- Itching
- Injection site reactions (redness, swelling)
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