What is Cefpirome?
Cefpirome is a fourth-generation cephalosporin antibiotic used in the treatment of bacterial infections, particularly those caused by susceptible organisms such as Streptococcus pneumoniae and Escherichia coli. It is administered intravenously and has a broad spectrum of activity, including against beta-lactamase-producing bacteria. Cefpirome works by inhibiting bacterial cell wall synthesis, ultimately leading to the death of the microorganism. Its use may vary depending on local resistance patterns and clinical guidelines.
What is Cefpirome used for?
Cefpirome is a fourth-generation cephalosporin antibiotic used to treat various bacterial infections, including those of the respiratory tract, urinary tract, and skin. It belongs to the class of beta-lactam antibiotics and functions by inhibiting the growth of bacterial cells through interference with cell wall synthesis.
The mechanism of action of cefpirome involves binding to penicillin-binding proteins (PBPs) located inside bacterial cells. This binding causes a disruption in the normal functioning of the PBP, which is essential for the bacteria’s ability to synthesize their peptidoglycan-rich cell walls. As a result of this disruption, the bacteria’s cell wall cannot form properly, leading to the death of the bacterial cell. Cefpirome has a broad spectrum of activity and can target both Gram-positive and Gram-negative bacteria.
In clinical practice, cefpirome is typically administered intravenously, often with repeated doses as necessary, depending on the type and severity of infection being treated. Due to its relatively good pharmacokinetic profile, it provides effective bactericidal action against a wide range of bacterial pathogens. However, antibiotic resistance can develop over time in certain bacteria species, making regular susceptibility testing essential for the optimal use of cefpirome in patient treatment.
Cefpirome side effects
• Abnormal taste • Allergic reactions (e.g., anaphylaxis, angioedema) • Confusion • Diarrhea • Dizziness • Fever • Headache • Increased bleeding tendency • Increased risk of infection with repeated doses • Insomnia • Itching • Liver damage • Muscle weakness • Nausea and vomiting • Overactive reflexes • Seizures (rare) • Sensitivity to sunlight • Skin rash • Stomach upset • Tremors
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