What is Cefpodoxime proxetil?
Cefpodoxime proxetil is an oral, third-generation cephalosporin antibiotic. It belongs to the class of beta-lactam antibiotics and exerts its antibacterial action by inhibiting cell wall synthesis in susceptible bacteria. Cefpodoxime proxetil has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including those commonly responsible for skin infections, respiratory tract infections, urinary tract infections, and gastrointestinal infections. It is often used to treat mild-to-moderate bacterial infections in adults and children over six months of age.
What is Cefpodoxime proxetil used for?
Cefpodoxime Proxetil: A Broad-Spectrum Antibiotic
Cefpodoxime proxetil is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It belongs to the class of beta-lactam antibiotics, which inhibit cell wall synthesis in bacteria, ultimately leading to their death. Cefpodoxime proxetil is available in both oral and intravenous forms.
Mechanism of Action and Uses
Cefpodoxime proxetil exerts its antibacterial action by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, resulting in the inhibition of cell wall synthesis. This mechanism ultimately leads to the death of bacteria. The antibiotic is effective against a wide range of Gram-positive and Gram-negative bacteria, including those that cause respiratory tract infections, urinary tract infections, skin infections, and gastrointestinal infections. It is also used to treat Lyme disease and other tick-borne illnesses. Cefpodoxime proxetil’s spectrum of activity includes many strains of Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, and Neisseria gonorrhoeae.
Important Considerations
Cefpodoxime proxetil is generally well-tolerated; however, as with any antibiotic, potential side effects include gastrointestinal symptoms, allergic reactions, diarrhea, and liver enzyme elevations. It is contraindicated in patients who have had a hypersensitivity reaction to cefpodoxime or other cephalosporins. In addition, it should be used with caution in patients with renal impairment, as cefpodoxime proxetil’s excretion may be altered in such cases.
Cefpodoxime proxetil side effects
- Diarrhea
- Headache
- Nausea and vomiting
- Abdominal pain
- Allergic reactions (e.g., skin rash, itching)
- Increased liver enzymes (transaminases)
- Cough
- Rhinitis
- Lymphadenopathy
- Eosinophilia
Disclaimer
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