What is Ceftaroline?
Ceftaroline is an injectable cephalosporin antibiotic used in the treatment of community-acquired pneumonia and skin infections caused by susceptible bacteria. It has broad-spectrum activity, including against Streptococcus pneumoniae and certain strains of Staphylococcus aureus. Ceftaroline inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial death. It is administered intravenously in a hospital setting for patients with severe infections requiring parenteral therapy.
What is Ceftaroline used for?
Ceftaroline is an intravenous antibiotic medication developed by Cephalon, Inc. (now a part of Allergan). It belongs to the class of cephalosporin antibiotics and is primarily used to treat severe infections caused by susceptible bacteria.
The mechanism of action of Ceftaroline involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins located inside the bacterial cell wall. This ultimately leads to the disruption of bacterial cell wall formation, causing the death of the bacterial cells. The drug has a broad spectrum of activity against Gram-positive and some Gram-negative bacteria.
Ceftaroline is particularly useful in treating patients with complicated skin and soft tissue infections (cSSSI), including those caused by methicillin-resistant Staphylococcus aureus (MRSA). It also treats community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) in adult patients.
Ceftaroline side effects
- Abdominal pain
- Allergic reactions (e.g., anaphylaxis)
- Angioedema
- Chest pain or discomfort
- Confusion
- Coughing up blood (hemoptysis)
- Diarrhea
- Dizziness
- Elevated liver enzymes
- Fatigue
- Headache
- Hypersensitivity reactions (e.g., rash, itching)
- Increased sweating
- Infection, secondary
- Lightheadedness
- Memory problems
- Muscle weakness
- Nausea and vomiting
- Pneumonia, aspergillus
- Seizures (rare)
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