What is Ceftaroline fosamil?
Ceftaroline fosamil, also known as Ceftaroline, is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections. It works by inhibiting cell wall synthesis in bacteria, ultimately leading to the death of the microorganisms. Ceftaroline has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and other resistant pathogens. It is typically administered intravenously or orally for patients with mild infections. The medication is used for community-acquired pneumonia, skin infections, and complicated urinary tract infections, among others.
What is Ceftaroline fosamil used for?
Ceftaroline fosamil is an injectable antibiotic that belongs to the cephalosporin class of medications. It is a broad-spectrum antimicrobial agent used to treat various bacterial infections, including pneumonia, skin and soft tissue infections, and pharyngitis (strep throat). Ceftaroline fosamil works by inhibiting the growth and replication of bacteria, ultimately leading to their death.
The mechanism of action of ceftaroline fosamil involves its binding to penicillin-binding proteins (PBPs) on the bacterial cell wall. This interaction disrupts the synthesis of peptidoglycan, a critical component of the bacterial cell wall, causing the bacterial cell to die. Ceftaroline fosamil is administered intravenously and is typically used in patients who require parenteral (intravenous) therapy. It has a relatively long half-life, allowing for once-daily dosing in some cases.
In terms of its pharmacokinetics, ceftaroline fosamil is rapidly absorbed after IV administration, with peak plasma concentrations achieved within 1 hour. Its volume of distribution is moderate to high, indicating that it distributes well into tissues throughout the body. The drug undergoes primarily renal elimination, with a small amount eliminated in the feces.
Ceftaroline fosamil has been shown to be effective against various pathogens, including Streptococcus pneumoniae, Staphylococcus aureus (methicillin-sensitive and methicillin-resistant), and other gram-positive bacteria. It also exhibits activity against some gram-negative bacteria, such as Escherichia coli.
Pharmacoepidemiological studies have suggested that ceftaroline fosamil is generally safe and well-tolerated when used appropriately in clinical settings.
Ceftaroline fosamil side effects
• Nausea • Diarrhea • Headache • Dizziness • Fatigue • Abdominal pain • Injection site reactions • Pruritus (itching) • Eosinophilia • Increased liver enzymes • Hypersensitivity reactions • QT interval prolongation
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