What is Ceftibuten dihydrate?
Ceftibuten dihydrate is an oral third-generation cephalosporin antibiotic. It has bactericidal activity against Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains. Ceftibuten is used to treat various infections such as pneumonia, bronchitis, urinary tract infections, and skin infections. The drug works by inhibiting cell wall synthesis in bacterial cells, ultimately leading to their death. Its dihydrate form is a stable salt that improves solubility and bioavailability.
What is Ceftibuten dihydrate used for?
Ceftibuten dihydrate is a semi-synthetic, broad-spectrum cephalosporin antibiotic of the third generation. It was developed as an oral prodrug that is rapidly converted to its active form, ceftibuten, upon administration.
Ceftibuten has a unique chemical structure that distinguishes it from other antibiotics in this class. Its dihydrate formulation is used to increase solubility and bioavailability, making it suitable for oral use. As a result of its conversion to the active metabolite, ceftibuten dihydrate exhibits potent antimicrobial activity against a wide range of bacterial species, including both Gram-positive and Gram-negative organisms.
Pharmacokinetic studies have shown that ceftibuten is well-absorbed from the gastrointestinal tract after oral administration, with maximum plasma concentrations typically reached within 1-2 hours. It then undergoes rapid elimination by the kidneys, resulting in a relatively short half-life. Ceftibuten dihydrate has been used effectively to treat various bacterial infections, including those involving the respiratory and urinary tracts, as well as skin and soft tissue infections.
Ceftibuten dihydrate side effects
• Abdominal pain • Diarrhea • Headache • Injection site reaction • Nausea • Pharyngitis • Pneumonia • Rash • Sinusitis • Vomiting
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