What is Ceftizoxime?
Ceftizoxime is a third-generation cephalosporin antibiotic used to treat bacterial infections caused by susceptible organisms such as Streptococcus pneumoniae, Escherichia coli, and Klebsiella species. It is administered intravenously and has a broad spectrum of activity against gram-negative bacteria. Ceftizoxime is also effective against some gram-positive bacteria, including Staphylococcus aureus. Its pharmacokinetic profile allows for once-daily dosing in most patients.
What is Ceftizoxime used for?
Ceftizoxime is a third-generation cephalosporin antibiotic that was first approved by the US Food and Drug Administration (FDA) in 1981. It belongs to the class of beta-lactam antibiotics, which are a broad group of antimicrobial agents that inhibit bacterial cell wall synthesis, leading to bacterial lysis and death.
Ceftizoxime is primarily used for the treatment of various bacterial infections, including urinary tract infections, skin and soft tissue infections, septicemia (bloodstream infection), and respiratory tract infections. It exhibits strong activity against a wide range of gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. Additionally, it shows efficacy against certain gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. Ceftizoxime is typically administered intravenously in patients who require parenteral antibiotic therapy due to its narrow therapeutic index. It has a broad spectrum of activity, making it a valuable option for treating bacterial infections that may be caused by multiple susceptible pathogens.
Ceftizoxime side effects
- Diarrhea
- Nausea and vomiting
- Abdominal pain
- Fever
- Headache
- Dizziness
- Seizure-like activity
- Behavioral changes
- Allergic reactions (hives, itching, difficulty breathing)
- Rare: Blood disorders (anemia, thrombocytopenia), liver enzyme elevations, jaundice, Stevens-Johnson syndrome, anaphylaxis.
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