What is Cephacetrile sodium?
Cephaloridine or cefaloridine is a first-generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH. Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity.
What is Cephacetrile sodium used for?
Cephacetrile sodium, also known as cephaloridine sodium salt, is an antibiotic that belongs to the cephalosporin class of medications. It was one of the first-generation cephalosporins developed in the early 1960s for the treatment of various bacterial infections. Cephaloridine has been used primarily as a parenteral agent for the intravenous and intramuscular administration, targeting susceptible bacteria that cause respiratory tract infections, urinary tract infections, skin and soft tissue infections, and some systemic infections.
Cephacetrile sodium’s antimicrobial spectrum includes several Gram-positive cocci (such as Staphylococcus aureus), certain Gram-negative rods (including Escherichia coli and Proteus mirabilis), and various anaerobic bacteria. The pharmacokinetic profile of cephacetrile sodium indicates moderate penetration into body tissues with good bioavailability following intramuscular injection but relatively limited entry after parenteral administration. As a result, its usage has been somewhat restricted due to the development of more effective, better-tolerated cephalosporins in recent years.
Cephacetrile sodium side effects
- Allergic reactions (such as rashes and itching)
- Angina pectoris
- Anxiety
- Arrhythmias
- Bleeding or bruising
- Coughing up blood
- Decreased heart rate
- Depression
- Difficulty speaking
- Dizziness
- Hiccup
- Hypotension
- Infection
- Increased risk of infections (such as fungal and bacterial)
- Low white blood cell count (leukopenia)
- Lymphadenopathy
- Nausea
- Palpitations
- Peptic ulcer disease
- Photosensitivity reaction
- Redness or swelling at injection site
- Shock
- Shortness of breath
- Skin rash
- Stevens-Johnson syndrome (rare, severe skin and mucous membrane condition)
- Stinging sensation
- Sweating
- Throat constriction
- Ulcerative stomatitis
- Vascular collapse
- Vasodilation
- Vomiting
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