What is Cephaloridine?
Cephaloridine, also known as Cefaloridina or 7-Chloro-1-(D-phosphono-methyl)pyridothio-[3’,2’:5,6]cephem-4-carboxylic acid, is a first-generation cephalosporin antibiotic. It was initially used to treat various bacterial infections, including urinary tract and skin infections. Cephaloridine acts by inhibiting cell wall synthesis in bacteria, ultimately leading to the death of the microorganism.
What is Cephaloridine used for?
Cephaloridine, also known as cefaloridin or cephalotidin, is a second-generation, broad-spectrum cephalosporin antibiotic that was first introduced in the 1960s. It belongs to the class of beta-lactam antibiotics, which inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This action results in the inhibition of the synthesis of the bacterial cell wall, ultimately leading to cell death.
Cephaloridine was used primarily to treat various infections caused by susceptible organisms, including those affecting the skin and soft tissues, respiratory tract, urinary tract, and gastrointestinal system. The drug exhibited a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. However, its use declined in the late 1970s due to reports of nephrotoxicity (kidney damage) and interstitial nephritis associated with cephaloridine therapy. This adverse effect limited the use of this antibiotic and led to the development and introduction of newer, safer alternatives within the same class.
Pharmacokinetics and Therapeutic Class
Cephaloridine has a pharmacokinetic profile characterized by rapid absorption after oral administration or intravenous injection, followed by extensive tissue distribution. The drug’s plasma half-life is relatively short, which requires frequent dosing to maintain therapeutic concentrations in the bloodstream. Cephaloridine’s broad-spectrum activity classifies it as a type of cephalosporin antibiotic that inhibits bacterial cell wall synthesis.
Cephaloridine side effects
- Skin rash
- Pruritus (itching)
- Flushing
- Urticaria (hives)
- Vasculitis
- Thrombocytopenia (low platelet count)
- Neutropenia (low white blood cell count)
- Anemia
- Gastrointestinal upset
- Nausea and vomiting
- Abdominal pain
- Diarrhea
- Stomatitis
- Fever
- Pain or discomfort
- Fatigue
- Weakness
- Headache
- Dizziness
- Seizures (rare)
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