What is Cephapirin?
Cephapirin is a broad-spectrum cephalosporin antibiotic that belongs to the third generation of cephalosporins. It is effective against a wide range of gram-negative bacteria, including Escherichia coli and Klebsiella pneumoniae. Cephapirin works by inhibiting cell wall synthesis in bacterial cells, ultimately leading to their death. The drug is commonly administered intramuscularly or subcutaneously for the treatment of various infections such as urinary tract infections, septicemia, and respiratory tract infections.
What is Cephapirin used for?
Cephapirin is an antibiotic medication belonging to the cephalosporin class of antibiotics. It was first synthesized in 1958 and was used primarily as a veterinary medicine for the treatment of bacterial infections in animals, particularly poultry and swine. The drug works by inhibiting the synthesis of bacterial cell walls, ultimately leading to the death of the bacteria.
Clinical Use
Cephapirin is a broad-spectrum antibiotic that is effective against both Gram-positive and Gram-negative bacteria. It is often used in the treatment of infections caused by E. coli, Staphylococcus aureus, and other susceptible organisms. The drug is typically administered intramuscularly or subcutaneously to achieve therapeutic concentrations in the bloodstream. Cephapirin has been found to be effective against a range of bacterial pathogens, including those responsible for respiratory tract infections, urinary tract infections, and skin and soft tissue infections.
Pharmacokinetics
Cephapirin is eliminated from the body primarily through renal excretion. The drug’s half-life in humans is relatively short, approximately 45-60 minutes. This allows for rapid elimination of the antibiotic from the body and minimizes the risk of adverse effects associated with prolonged exposure to the medication.
Adverse Effects
Cephapirin can cause a range of side effects, including hypersensitivity reactions, injection site reactions, and gastrointestinal disturbances such as diarrhea and vomiting. Rarely, more serious adverse events may occur, including seizures, anaphylaxis, and hemolysis in individuals with glucose-6-phosphate dehydrogenase deficiency.
Cephapirin side effects
- Bacterial and fungal infections (e.g., Clostridioides difficile infection)
- Allergic reactions
- Hives
- Itching
- Swelling, especially of the face, lips, tongue, or throat
- Gastrointestinal symptoms
- Diarrhea
- Vomiting
- Nausea
- Abdominal pain
- Headache
- Dizziness
- Fever
- Increased sweating
- Flushing
- Insomnia
- Seizures (rare)
- Hypersensitivity reactions (e.g., anaphylaxis, angioedema)
Disclaimer
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