What is Cephradine?
Cephradine is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections, including pneumonia, skin and soft tissue infections, urinary tract infections, and respiratory tract infections. It works by inhibiting the synthesis of cell walls in bacteria, ultimately leading to their death. Cephradine is administered orally and is available as a tablet or suspension for pediatric use. Its effectiveness has been demonstrated against both Gram-positive and Gram-negative bacteria, although its activity may vary depending on the specific microorganism involved.
What is Cephradine used for?
Cephradine, also known as Cefradine or Klavunat, is an oral cephalosporin antibiotic used to treat various bacterial infections. It belongs to the second generation of cephalosporins and possesses a broad spectrum of activity against Gram-positive and some Gram-negative bacteria. The mechanism of action involves inhibiting cell wall synthesis in susceptible organisms by binding to penicillin-binding proteins, ultimately leading to cell lysis and death.
Pharmacological Properties
Cephradine is administered orally and has good bioavailability, typically achieving peak plasma concentrations within 1-2 hours after dosing. The antibiotic exhibits a stable and predictable absorption profile when taken with or without food. It undergoes limited hepatic metabolism and excretion primarily in the urine, but renal function does not significantly influence its pharmacokinetics. Cephradine has been found to be safe for use in adults and pediatric patients of various ages, although its efficacy and safety have not been established for all susceptible organisms. The most common side effects reported with cephradine include gastrointestinal disturbances, allergic reactions, and transient elevations in liver function tests. However, serious adverse events are rare with this antibiotic.
Clinical Applications
Cephradine is indicated to treat infections such as streptococcal pharyngitis (streptococcal sore throat), skin and soft tissue infections (e.g., folliculitis), respiratory tract infections, and urinary tract infections caused by susceptible bacteria. It has also been used in combination with other antibiotics for the treatment of certain gram-negative bacterial infections and as prophylaxis to prevent surgical site infections. Despite its potential benefits, cephradine’s effectiveness may be compromised in cases where β-lactamase-producing organisms are involved or when other factors contribute to antibiotic resistance.
Dosage and Administration
The dosage regimen for cephradine typically involves a single daily dose of 250-500 mg per adult patient, adjusted according to the severity of infection. Treatment duration usually ranges from 5 to 10 days but may vary depending on clinical response and laboratory findings.
Cephradine side effects
- Diarrhea
- Abdominal pain or cramping
- Nausea and vomiting
- Dizziness or lightheadedness
- Headache
- Allergic reactions (such as rash, itching, or swelling)
- Throat irritation
- Mild fever
- Joint pain or stiffness
- Stomach upset or tenderness
- Constipation
- Fatigue
- Increased sensitivity to the sun or other UV light
- Muscle weakness
- Tinnitus (ringing in the ears)
- Decreased sense of taste
- Vaginal itching or discharge
Disclaimer
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