What is Cinoxacin?
Cinoxacin is an antibacterial agent used to treat urinary tract infections (UTIs) and other bacterial infections, particularly those caused by gram-positive bacteria. It works by inhibiting DNA synthesis in the bacterial cell wall, ultimately leading to bacterial death. Cinoxacin was approved for use in the United States in 1977 under the brand name Cinoben; however, its use has been largely limited due to the emergence of resistance among target pathogens and the availability of more effective alternative treatments.
What is Cinoxacin used for?
Cinoxacin, also known as Cinobacin or Cinomycin, is an antibiotic medication belonging to the quinolone class. It was first synthesized in the 1970s and introduced into clinical practice in the early 1980s for the treatment of bacterial infections.
Cinoxacin has been used primarily to treat urinary tract infections (UTIs), such as pyelonephritis and cystitis, caused by susceptible bacteria like Escherichia coli (E. coli) and Staphylococcus saprophyticus. It works by inhibiting DNA gyrase and topoisomerase IV enzymes in bacterial cells, which are essential for the replication of DNA and transcription of genetic material. This action results in the death of rapidly multiplying bacteria.
As a quinolone antibiotic, Cinoxacin exerts its antibacterial effect by targeting both gram-positive and gram-negative bacteria. Its oral bioavailability is moderate to high, allowing for effective absorption after ingestion. Despite its use as an antibiotic, there have been concerns raised about the potential development of resistance among bacterial pathogens due to its widespread application.
In general clinical practice, Cinoxacin has been used in combination with other antibiotics or administered orally at doses ranging from 500-750 milligrams per day, depending on the severity and type of infection being treated. However, it is essential for patients to follow a prescribed treatment course carefully and consult their healthcare provider if symptoms persist or worsen.
Key Therapeutic Use: Urinary tract infections (UTIs)
Cinoxacin side effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
- Fatigue
- Skin rash
- Allergic reactions (rare)
- Increased risk of sunburn or skin sensitivity to the sun
- Decreased blood counts (rare)
Disclaimer
The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.