What is Clevidipine?
Clevidipine is an intravenous calcium channel blocker used to manage hypertension, particularly in acute settings such as cardiovascular surgery and post-cardiac arrest care. It works by relaxing the muscles of the heart and blood vessels to lower high blood pressure. Clevidipine is administered directly into a vein and its effects typically last for about 15-20 minutes, allowing for rapid titration to achieve desired blood pressure levels.
What is Clevidipine used for?
Clevidipine, also known as Cleviprex in some countries, is an intravenous calcium channel blocker primarily used in the acute management of hypertension during and immediately after cardiovascular surgery. It was approved by the U.S. Food and Drug Administration (FDA) in 2008 for this specific indication.
This medication works by selectively targeting the L-type calcium channels in smooth muscle cells, leading to vasodilation and subsequent lowering of blood pressure. Unlike other antihypertensive agents that may cause reflex tachycardia or affect cardiac output, clevidipine tends to maintain or even slightly increase systemic vascular resistance while reducing afterload. As a result, it can be beneficial in preserving the cardiovascular function during and postoperatively in patients undergoing cardiothoracic surgery.
As with any medication, its administration should strictly follow specific guidelines, including precise dosing instructions to avoid hypotension and ensure adequate blood pressure control without causing undue cardiac stress. The use of clevidipine is typically monitored closely by medical professionals to prevent these complications, especially in elderly patients or those with pre-existing cardiovascular disease.
Clevidipine side effects
- Hypotension
- Dizziness
- Headache
- Peripheral edema
- Increased heart rate
- Ventricular extrasystoles
- Tachycardia
- Chest pain
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Hypertension
- Bradycardia
- Cerebrovascular accident
Disclaimer
The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.