What is Clevidipine-bumetanide?
Clevidipine-bumetanide, also known as Clevidipine, is an injectable calcium channel blocker used in the management of hypertension. It works by selectively blocking L-type calcium channels, leading to a decrease in peripheral vascular resistance and blood pressure. The addition of bumetanide, a potent loop diuretic, enhances the drug’s antihypertensive effects while allowing for controlled fluid administration. Clevidipine is used primarily during emergency situations, such as cardiac arrest or unstable angina, where quick and precise control of blood pressure is critical.
What is Clevidipine-bumetanide used for?
Clevidipine-bumetanide, also known as Ongentys or Clevidipine, is an intravenous calcium channel blocker that has been developed for the management of acute hypertension. This medication belongs to a class of antihypertensive drugs that work by inhibiting the entry of calcium ions into smooth muscle cells of blood vessels.
Clevidipine-bumetanide is used in hospital settings to rapidly lower blood pressure in critically ill patients who have experienced a rapid increase in blood pressure. The medication’s onset of action occurs within 1-2 minutes after administration, and its effects typically last for approximately 20 minutes before needing readministration or switching to an oral antihypertensive agent. By quickly reducing blood pressure, clevidipine-bumetanide can help prevent complications associated with uncontrolled hypertension in critically ill patients.
As a pharmacological intervention, clevidipine-bumetanide combines the vasodilatory effects of calcium channel blockade with the diuretic action of bumetanide to manage both blood pressure and fluid balance. The combination of these two mechanisms of action allows for more comprehensive management of hypertension in critically ill patients.
The medication’s development reflects a growing understanding of the need for targeted, rapidly acting treatments that can address specific clinical challenges associated with acute hypertension.
Clevidipine-bumetanide side effects
- Hypotension
- Dizziness
- Headache
- Nausea
- Vomiting
- Diarrhea
- Increased blood urea nitrogen (BUN)
- Increased creatinine
- Renal impairment
- Hyperkalemia
- Bradycardia
- Tachycardia
- Orthostatic hypotension
- Chest pain
- Palpitations
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