What is Colistin?
Colistin, also known as polymyxin E, is an antibiotic medication used to treat certain bacterial infections. It works by disrupting the cell membrane of bacteria, ultimately killing them. Colistin is effective against gram-negative bacteria and has been reserved for use in severe or life-threatening cases due to its potential toxicity and limited availability.
What is Colistin used for?
Colistin, also known as polymyxin E, is a bactericidal antibiotic that belongs to the polymyxin class of antibiotics. It is a potent inhibitor of bacterial protein synthesis and has been used for decades in treating various bacterial infections. Colistin is composed of several related peptides, with colistin sulfomethane sodium being the most commonly used form.
Colistin’s mechanism of action involves binding to the lipid bilayer of bacterial cell membranes, causing structural changes that ultimately lead to cell lysis and death. Its spectrum of activity includes a wide range of Gram-negative bacteria, including multidrug-resistant strains such as Pseudomonas aeruginosa and Acinetobacter baumannii. Colistin is often used in combination with other antibiotics or as part of an antibiotic therapy regimen for treating severe infections.
Indications and Administration
Colistin is typically administered intravenously (IV) or orally, although its use may vary depending on the patient’s condition and local guidelines. Common indications for colistin include hospital-acquired pneumonia, ventilator-associated pneumonia, sepsis, urinary tract infections, and complicated intra-abdominal infections. The drug should only be used under strict supervision by healthcare professionals due to its potential for nephrotoxicity (kidney damage) and neurotoxicity (nerve damage). Dosage regimens may need to be adjusted based on the patient’s renal function and antibiotic sensitivity.
Colistin side effects
- Anaphylaxis
- Bronchospasm
- Chills
- Confusion
- Cough
- Decreased white blood cell count (agranulocytosis)
- Diarrhea
- Fever
- Hearing loss
- Increased liver enzymes
- Nausea
- Respiratory distress or failure
Disclaimer
The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.