Dapagliflozin-metformin

What is Dapagliflozin-metformin?

Dapagliflozin-metformin, also known as XIGDUO XR, is an oral anti-diabetic combination medication used to treat type 2 diabetes. It contains the fixed-dose combination of dapagliflozin and metformin, which helps to lower blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver. Dapagliflozin-metformin works by inhibiting sodium-glucose cotransporter 2 (SGLT2) and reducing glucose reabsorption, while also decreasing glucose output from the liver through its metformin component. This medication is available in extended-release form and is taken once daily to improve glycemic control and reduce the risk of diabetic-related complications.

What is Dapagliflozin-metformin used for?

Dapagliflozin-Metformin, also known as Xigduo XR in the United States, is an oral medication that combines two active ingredients: dapagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, and metformin, a biguanide antidiabetic agent. The combination of these two medications was designed to provide a dual-action approach in the management of type 2 diabetes mellitus.

Mechanism of Action

The mechanism of action of Dapagliflozin-Metformin involves dapagliflozin inhibiting the reabsorption of glucose in the kidneys, thereby reducing blood glucose levels. This is achieved through the inhibition of SGLT-2, a transporter responsible for the majority of glucose reabsorption in the kidney tubules. At the same time, metformin acts by decreasing glucose production in the liver and increasing insulin sensitivity, further contributing to improved glycemic control. By combining these two mechanisms, Dapagliflozin-Metformin offers an innovative approach to managing type 2 diabetes by enhancing both renal glucose excretion and peripheral insulin sensitivity.

Indications and Dosage

Dapagliflozin-Metformin is indicated as a once-daily tablet for the treatment of adults with type 2 diabetes who are unable to achieve adequate glycemic control on diet and exercise alone. The recommended starting dose is one tablet of Dapagliflozin-Metformin 10 mg/1000 mg, taken orally in the morning with water before eating, once daily. The dosage may be adjusted according to the patient’s response and tolerance.

Dapagliflozin-metformin side effects

  1. Diarrhea
  2. Nausea
  3. Vomiting
  4. Stomach pain
  5. Headache
  6. Fatigue
  7. Dizziness
  8. Abdominal discomfort
  9. Muscle pain
  10. Joint pain
  11. Increased urination
  12. Dehydration
  13. Hypoglycemia (low blood sugar)
  14. Anemia
  15. Thirst
  16. Dry mouth
  17. Cold-like symptoms (e.g., runny nose, sneezing)
  18. Flu-like symptoms (e.g., fever, chills)
  19. Weight loss
  20. Increased risk of urinary tract infections

Disclaimer

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