What is Demeclocycline?
Demeclocycline, also known as Decapen, is a semi-synthetic derivative of tetracycline antibiotic used in the treatment of various bacterial infections. It belongs to the class of chemotherapeutic agents and is characterized by its unique pharmacological properties that distinguish it from other members of the tetracycline family. Demeclocycline exerts its antibacterial effects by inhibiting protein synthesis through binding to the 30S subunit of the ribosome, ultimately leading to bacterial cell death.
What is Demeclocycline used for?
Demeclocycline is a semi-synthetic, broad-spectrum antibiotic belonging to the tetracycline class of drugs. It was first synthesized in the 1960s and has been used in various forms of treatment for several decades. As a tetracycline derivative, demeclocycline shares similarities with other members of this class in its mechanism of action. However, it possesses distinct characteristics that set it apart from others within the same group.
Demeclocycline’s therapeutic use primarily targets infections caused by gram-positive bacteria, such as Staphylococcus aureus, and some gram-negative organisms like Escherichia coli (E. coli). Its broad-spectrum activity allows for treatment of various types of bacterial infections. Moreover, demeclocycline has been used off-label in certain medical conditions where its unique properties are beneficial, including for management of resistant Staphylococcus aureus and some types of psoriasis. Overall, the drug’s spectrum of efficacy makes it a valuable asset in managing bacterial infections when traditional antibiotic options fail or as part of combination therapy protocols.
The pharmacokinetic profile of demeclocycline indicates moderate oral bioavailability after administration, which is somewhat lower compared to other tetracyclines. Following absorption, demeclocycline undergoes distribution and extensive metabolism before being eliminated primarily via the kidneys in its metabolized form.
Demeclocycline side effects
- Allergic reactions: rare
- Altered bowel function
- Aphthous stomatitis
- Diarrhea
- Dizziness
- Dyspepsia
- Hiccup
- Increased BUN
- Increased bilirubin
- Increased gamma-GT
- Increased LDH
- Increased transaminases
- Increased urine calcium
- Itching
- Nausea
- Photosensitivity reaction
- Pneumonia
- Vaginal candidiasis
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