What is Doripenem?
Doripenem is a carbapenem antibiotic used in the treatment of serious bacterial infections, such as pneumonia and urinary tract infections. It works by inhibiting cell wall synthesis in susceptible bacteria, ultimately leading to their death. Doripenem has broad-spectrum activity against both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. It is administered intravenously and is often used when other antibiotics have failed or are not suitable due to resistance concerns.
What is Doripenem used for?
Doripenem is an injectable carbapenem antibiotic that belongs to the class of beta-lactam antibiotics. It was developed by Johnson & Johnson and Pfizer as a newer generation of carbapenems with improved spectrum of activity against gram-negative bacteria, including Pseudomonas aeruginosa.
The pharmacological profile of doripenem is characterized by its broad-spectrum antibacterial properties, which are attributed to its ability to inhibit bacterial cell wall synthesis. Doripenem exerts its bactericidal effects on a wide range of Gram-positive and Gram-negative bacteria, including those that produce beta-lactamases, making it effective against many multidrug-resistant strains. The medication is administered intravenously, typically in a hospital setting, for the treatment of complicated urinary tract infections (cUTIs) and intra-abdominal infections caused by susceptible pathogens.
Doripenem side effects
• Nausea • Vomiting • Diarrhea • Abdominal pain • Headache • Dizziness • Rash • Itching • Pruritus • Flushing • Injection site reactions (pain, swelling, redness) • Increased liver enzymes • Altered taste • Insomnia • Confusion • Seizures • Hypersensitivity reactions (anaphylaxis, angioedema)
Disclaimer
The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.