What is Dulaglutide-insulin degludec?
Xultophy (Insulin Degludec and Liraglutide) combines insulin degludec, a long-acting basal insulin analog, with liraglutide, an glucagon-like peptide-1 receptor agonist. It is used in the management of type 2 diabetes to improve glycemic control.
What is Dulaglutide-insulin degludec used for?
Drug Name: Trulicity (dulaglutide) / NovoLog (insulin aspart) + Levemir (insulin detemir), combination of three drugs is not available. However, I will provide information on two separate medications.
- Trulicity (Dulaglutide): Dulaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the management of type 2 diabetes mellitus. It helps to lower blood glucose levels by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying. Additionally, dulaglutide has been shown to have weight loss benefits and reduce cardiovascular risk factors.
Indications: Trulicity is indicated as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes mellitus to improve glycemic control in conjunction with diet and exercise, and to reduce the risk of major adverse cardiovascular events (MACE) in adults with established atherosclerotic CVD.
- NovoLog (Insulin Aspart): Insulin aspart is a rapid-acting insulin used for the treatment of type 1 diabetes and certain types of diabetes-related complications. It helps to lower blood glucose levels by stimulating glucose uptake into cells. NovoLog has an onset of action within 15 minutes, peaks between 1-3 hours, and has a duration of effect lasting about 2-4 hours.
Indications: NovoLog is indicated for the treatment of adults with type 1 diabetes mellitus, as well as those with diabetes-related complications such as diabetic ketoacidosis.
- Levemir (Insulin Detemir): Insulin detemir is a long-acting insulin used in conjunction with other diabetes medications to improve glycemic control in people with type 1 or type 2 diabetes. It has an onset of action within 30 minutes, peaks between 6-10 hours, and provides a steady background level of insulin for up to 24 hours.
Indications: Levemir is indicated as a basal insulin in combination with other diabetes medications (oral glucose-lowering drugs) or as part of the treatment regimen with basal insulins like glargine. It helps maintain normal blood sugar levels during periods when diet and exercise alone may not be sufficient, providing stability to daily glucose levels throughout the day.
Dulaglutide-insulin degludec side effects
- Hypoglycemia
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Injection site reactions
- Muscle or back pain
- Fatigue
- Headache
- Dizziness
- Flu-like symptoms
- Constipation
- Increased liver enzymes (elevated ALT and AST)
- Lipodystrophy at the injection site
- Serious allergic reactions (hypersensitivity)
- Increased incidence of pancreatitis
- Thyroid C-cell tumors
- Acute kidney injury
- Pancreatic cancer
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