What is Empagliflozin-linagliptin?
Xultophy is an antidiabetic fixed-dose combination of empagliflozin (a sodium-glucose cotransporter 2 inhibitor) and linagliptin (a dipeptidyl peptidase-4 inhibitor). It works by reducing glucose reabsorption in the kidneys and increasing insulin secretion, thereby lowering blood glucose levels. Empagliflozin helps to remove excess glucose from the urine, while linagliptin enhances insulin production. The combination is used as an adjunct to diet and exercise for the treatment of type 2 diabetes mellitus.
What is Empagliflozin-linagliptin used for?
Generic Name: Empagliflozin-Linagliptin; Brand Name: Synjardy, Glyxambi
Synjardy (empagliflozin-linagliptin) and Glyxambi (empagliflozin-linagliptin) are fixed-dose combination medications comprising two oral antidiabetic agents: empagliflozin and linagliptin. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, thus increasing the excretion of glucose through urine. This results in decreased blood sugar levels.
Linagliptin, on the other hand, belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitors class. It inhibits the enzyme DPP-4 and thereby slows down the breakdown of incretin hormones (GLP-1 and GIP). Incretins stimulate insulin secretion in response to high glucose levels while simultaneously decreasing glucagon release, ultimately lowering blood glucose concentrations. The co-administration of empagliflozin and linagliptin has been demonstrated to improve glycemic control in type 2 diabetic patients, making it a valuable option for managing the condition.
Empagliflozin-linagliptin side effects
- Increased risk of genital yeast infections
- Urinary tract infection
- Kidney problems or worsening kidney disease
- Bladder cancer (if you have a history of bladder cancer)
- Pancreatitis
- Increased blood sugar levels in people with type 1 diabetes mellitus
- Serious allergic reactions (rash, hives, itching)
- Joint pain and inflammation
- Injection site reactions (pain, redness, swelling)
- Abnormal heart sounds or rhythms
- Changes in certain blood tests indicating potential problems with the liver or pancreas
- Increased risk of bone fractures
- Blood clots in the lungs or legs
- Headache
- Dizziness
- Stomach pain
- Vomiting
- Fatigue
- Muscle pain
- Cold sweats
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